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Literature summary for 3.4.24.11 extracted from

  • Betts, V.; Leissring, M.A.; Dolios, G.; Wang, R.; Selkoe, D.J.; Walsh, D.M.
    Aggregation and catabolism of disease-associated intra-Abeta mutations: reduced proteolysis of AbetaA21G by neprilysin (2008), Neurobiol. Dis., 31, 442-450.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine in the Flemish variant of amyloid beta, resistance to degradation by nepriylsin may underlie the pathogenicity associated with the A21G mutantion in amyloid beta Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
amyloid beta(1-40) mutant A21G + H2O Flemish variant of amyloid beta. Decreased degradation by neprilysin compared to either wild-type peptide or the other mutant peptides Homo sapiens ?
-
 ?
amyloid beta(1-40) mutant D23N + H2O Iowa variant of amyloid beta Homo sapiens ?
-
 ?
amyloid beta(1-40) mutant E22G + H2O Arctic variant of amyloid beta Homo sapiens ?
-
 ?
amyloid beta(1-40) mutant E22K + H2O Italian variant of amyloid beta Homo sapiens ?
-
 ?
amyloid beta(1-40) mutant E22Q + H2O Dutch variant of amyloid beta Homo sapiens ?
-
 ?
amyloid beta(1-40) peptide + H2O
-
 Homo sapiens ?
-
 ?