Literature summary for 3.4.24.11 extracted from

Spencer, B.; Marr, R.A.; Rockenstein, E.; Crews, L.; Adame, A.; Potkar, R.; Patrick, C.; Gage, F.H.; Verma, I.M.; Masliah, E.
Long-term neprilysin gene transfer is associated with reduced levels of intracellular Abeta and behavioral improvement in APP transgenic mice (2008), BMC Neurosci., 9, 109.

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Application

Application	Comment	Organism
medicine	sustained expression of a lentiviral vector carrying the neprilysin gene in amyloid precursor protein transgenic mice for up to 6 months lowers not only the amyloid plaque load but also reduces the levels of intracellular amyloid beta immunoreactivity. This is associated with improved behavioral performance in the water maze test and ameliorates the dendritic and synaptic pathology in the amyloid precursor protein transgenic mice	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
expression in amyloid precursor protein transgenic mice	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
E585V	inactive	Homo sapiens
additional information	sustained expression of a lentiviral vector carrying the neprilysin gene in amyloid precursor protein transgenic mice for up to 6 months lowers not only the amyloid plaque load but also reduces the levels of intracellular amyloid beta immunoreactivity. This is associated with improved behavioral performance in the water maze test and ameliorates the dendritic and synaptic pathology in the amyloid precursor protein transgenic mice	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	expression in mouse	-

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Release 2023.1 (January 2023)