Literature summary for 3.4.24.11 extracted from

El-Amouri, S.S.; Zhu, H.; Yu, J.; Marr, R.; Verma, I.M.; Kindy, M.S.
Neprilysin: an enzyme candidate to slow the progression of Alzheimer's disease (2008), Am. J. Pathol., 172, 1342-1354.

Search for more literature for 3.4.24.11

Application

Application	Comment	Organism
medicine	overexpression of human neprilysin for 4 months in young amyloid precursor protein//DeltaPS1 double-transgenic mice results in reduction in amyloid beta peptide levels, attenuation of amyloid load, oxidative stress, and inflammation, and improved spatial orientation. The overall reduction in amyloidosis and associated pathogenetic changes in the brain results in decreased memory impairment by about 50%	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
expression in mouse brain	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	overexpression of human neprilysin for 4 months in young amyloid precursor protein//DeltaPS1 double-transgenic mice results in reduction in amyloid beta peptide levels, attenuation of amyloid load, oxidative stress, and inflammation, and improved spatial orientation. The overall reduction in amyloidosis and associated pathogenetic changes in the brain results in decreased memory impairment by about 50%	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	transgenic expression in mouse	-

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Release 2023.1 (January 2023)