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Literature summary for 3.4.24.11 extracted from

  • Marr, R.A.; Guan, H.; Rockenstein, E.; Kindy, M.; Gage, F.H.; Verma, I.; Masliah, E.; Hersh, L.B.
    Neprilysin regulates amyloid Beta peptide levels (2004), J. Mol. Neurosci., 22, 5-11.
    View publication on PubMed
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Application

Application Comment Organism
medicine neprilysin can reduce the size and number of Abeta deposits in a transgenic mouse model. Neprilysin gene transfer therapy or other methods to increase endogenous neprilysin activity have the potential to prevent the accumulation of the amyloid Abeta peptide and as such may be able to prevent or delay the onset of Alzheimer#s disease Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
phosphoramidon
-
 Mus musculus
thiorphan
-
 Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-
hippocampus neurons Mus musculus
-
neuron hippocampal Mus musculus
-

Synonyms

Synonyms Comment Organism
NEP
-
 Mus musculus