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Literature summary for 3.4.24.11 extracted from

  • Pryde, D.C.; Maw, G.N.; Planken, S.; Platts, M.Y.; Sanderson, V.; Corless, M.; Stobie, A.; Barber, C.G.; Russell, R.; Foster, L.; Barker, L.; Wayman, C.; Van Der Graaf, P.; Stacey, P.; Morren, D.; Kohl, C.; Beaumont, K.; Coggon, S.; Tute, M.
    Novel selective inhibitors of neutral endopeptidase for the treatment of female sexual arousal disorder. Synthesis and activity of functionalized glutaramides (2006), J. Med. Chem., 49, 4409-4424.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2-([1-[(1,3-benzodioxol-5-ylmethyl)carbamoyl]cyclopentyl]methyl)pentanoic acid IC50: 1500 nM Canis lupus familiaris
2-([1-[(1-benzyl-2-hydroxyethyl)carbamoyl]cyclopentyl]methyl)pentanoic acid IC50: 384 nM Canis lupus familiaris
2-([1-[(1-benzyl-6-oxo-1,6-dihydropyridin-3-yl)carbamoyl]cyclopentyl]methyl)pentanoic acid IC50: 313 nM Canis lupus familiaris
2-([1-[(1-ethyl-1H-1,2,3-triazol-4-yl)carbamoyl]cyclopentyl]methyl)pentanoic acid IC50: 82 nM Canis lupus familiaris
2-([1-[(3-ethylpyridin-2-yl)carbamoyl]cyclopentyl]methyl)pentanoic acid IC50: 1710 nM Canis lupus familiaris
2-([1-[(4-benzylpyridin-2-yl)carbamoyl]cyclopentyl]methyl)pentanoic acid IC50: 96 nM Canis lupus familiaris
2-([1-[(4-butylpyridin-2-yl)carbamoyl]cyclopentyl]methyl)pentanoic acid IC50: 184 nM Canis lupus familiaris
2-([1-[(4-carbamoylcyclohexyl)carbamoyl]cyclopentyl]methyl)pentanoic acid IC50: 150 nM Canis lupus familiaris
2-([1-[(5-benzyl-1,3,4-thiadiazol-2-yl)carbamoyl]cyclopentyl]methyl)pentanoic acid IC50: 30 nM Canis lupus familiaris
2-([1-[(5-ethyl-1,3,4-thiadiazol-2-yl)carbamoyl]cyclopentyl]methyl)-4-phenylbutanoic acid IC50: 46 nM Canis lupus familiaris
2-([1-[(5-ethyl-1,3,4-thiadiazol-2-yl)carbamoyl]cyclopentyl]methyl)-5-methylhexanoic acid IC50: 120 nM Canis lupus familiaris
2-([1-[(5-ethyl-1,3,4-thiadiazol-2-yl)carbamoyl]cyclopentyl]methyl)hexanoic acid IC50: 84 nM Canis lupus familiaris
2-([1-[(5-ethyl-1,3,4-thiadiazol-2-yl)carbamoyl]cyclopentyl]methyl)pentanoic acid IC50: 60 nM Canis lupus familiaris
2-([1-[(5-methyl-1,3,4-thiadiazol-2-yl)carbamoyl]cyclopentyl]methyl)pentanoic acid IC50: 176 nM Canis lupus familiaris
2-([1-[(5-phenyl-1,3,4-thiadiazol-2-yl)carbamoyl]cyclopentyl]methyl)pentanoic acid IC50: 283 nM Canis lupus familiaris
2-([1-[(6-methoxypyridazin-3-yl)carbamoyl]cyclopentyl]methyl)pentanoic acid IC50: 374 nM Canis lupus familiaris
2-([1-[5-(1-benzyl-6-oxo-1,6-dihydropyridin-3-yl)-1,3,4-oxadiazol-2-yl]cyclopentyl]methyl)pentanoic acid IC50: 1139 nM Canis lupus familiaris
2-[(1-[[(1R)-1-phenylethyl]carbamoyl]cyclopentyl)methyl]pentanoic acid IC50: 530 nM Canis lupus familiaris
2-[(1-[[(1R)-3-(dimethylcarbamoyl)cyclohexyl]carbamoyl]cyclopentyl)methyl]pentanoic acid IC50: 297 nM Canis lupus familiaris
2-[(1-[[(1R,2R)-2-benzylcyclohexyl]carbamoyl]cyclopentyl)methyl]pentanoic acid IC50: 195 nM Canis lupus familiaris
2-[(1-[[(1R,2S)-2-propylcyclohexyl]carbamoyl]cyclopentyl)methyl]pentanoic acid IC50: 890 nM Canis lupus familiaris
2-[(1-[[(3R)-1-benzylpyrrolidin-3-yl]carbamoyl]cyclopentyl)methyl]pentanoic acid IC50: 1060 nM Canis lupus familiaris
2-[(1-[[(3R)-1-carbamoylpyrrolidin-3-yl]carbamoyl]cyclopentyl)methyl]pentanoic acid IC50: 213 nM Canis lupus familiaris
2-[(1-[[(5-methyl-1,3,4-thiadiazol-2-yl)methyl]carbamoyl]cyclopentyl)methyl]pentanoic acid IC50: 700 nM Canis lupus familiaris
2-[(1-[[1-(hydroxymethyl)cyclopentyl]carbamoyl]cyclopentyl)methyl]pentanoic acid IC50: 1710 nM Canis lupus familiaris
2-[(1-[[2-(hydroxymethyl)-2,3-dihydro-1H-inden-2-yl]carbamoyl]cyclopentyl)methyl]pentanoic acid IC50: 96 nM Canis lupus familiaris
2-[(1-[[4-(dimethylcarbamoyl)cyclohexyl]carbamoyl]cyclopentyl)methyl]pentanoic acid IC50: 370 nM Canis lupus familiaris
2-[(1-[[5-(2-methylpropyl)-1,3,4-thiadiazol-2-yl]carbamoyl]cyclopentyl)methyl]pentanoic acid IC50: 124 nM Canis lupus familiaris
2-[(1-[[5-(cyclopropylmethyl)-1,3,4-thiadiazol-2-yl]carbamoyl]cyclopentyl)methyl]pentanoic acid IC50: 38 nM Canis lupus familiaris
2-[[1-(1,3,4-thiadiazol-2-ylcarbamoyl)cyclopentyl]methyl]pentanoic acid IC50: 377 nM Canis lupus familiaris
2-[[1-(2,3-dihydro-1H-inden-2-ylcarbamoyl)cyclopentyl]methyl]pentanoic acid IC50: 313 nM Canis lupus familiaris
2-[[1-(5-benzyl-1,3,4-oxadiazol-2-yl)cyclopentyl]methyl]pentanoic acid IC50: 3100 nM Canis lupus familiaris
2-[[1-(pyridin-2-ylcarbamoyl)cyclopentyl]methyl]pentanoic acid IC50: 1500 nM Canis lupus familiaris
3-[1-[(5-ethyl-1,3,4-thiadiazol-2-yl)carbamoyl]cyclopentyl]propanoic acid IC50: 237 nM Canis lupus familiaris

Organism

Organism UniProt Comment Textmining
Canis lupus familiaris
-
-
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00003
-
IC50: 30 nM Canis lupus familiaris 2-([1-[(5-benzyl-1,3,4-thiadiazol-2-yl)carbamoyl]cyclopentyl]methyl)pentanoic acid
0.000038
-
IC50: 38 nM Canis lupus familiaris 2-[(1-[[5-(cyclopropylmethyl)-1,3,4-thiadiazol-2-yl]carbamoyl]cyclopentyl)methyl]pentanoic acid
0.000046
-
IC50: 46 nM Canis lupus familiaris 2-([1-[(5-ethyl-1,3,4-thiadiazol-2-yl)carbamoyl]cyclopentyl]methyl)-4-phenylbutanoic acid
0.00006
-
IC50: 60 nM Canis lupus familiaris 2-([1-[(5-ethyl-1,3,4-thiadiazol-2-yl)carbamoyl]cyclopentyl]methyl)pentanoic acid
0.000082
-
IC50: 82 nM Canis lupus familiaris 2-([1-[(1-ethyl-1H-1,2,3-triazol-4-yl)carbamoyl]cyclopentyl]methyl)pentanoic acid
0.000084
-
IC50: 84 nM Canis lupus familiaris 2-([1-[(5-ethyl-1,3,4-thiadiazol-2-yl)carbamoyl]cyclopentyl]methyl)hexanoic acid
0.000096
-
IC50: 96 nM Canis lupus familiaris 2-[(1-[[2-(hydroxymethyl)-2,3-dihydro-1H-inden-2-yl]carbamoyl]cyclopentyl)methyl]pentanoic acid
0.000096
-
IC50: 96 nM Canis lupus familiaris 2-([1-[(4-benzylpyridin-2-yl)carbamoyl]cyclopentyl]methyl)pentanoic acid
0.00012
-
IC50: 120 nM Canis lupus familiaris 2-([1-[(5-ethyl-1,3,4-thiadiazol-2-yl)carbamoyl]cyclopentyl]methyl)-5-methylhexanoic acid
0.000124
-
IC50: 124 nM Canis lupus familiaris 2-[(1-[[5-(2-methylpropyl)-1,3,4-thiadiazol-2-yl]carbamoyl]cyclopentyl)methyl]pentanoic acid
0.00015
-
IC50: 150 nM Canis lupus familiaris 2-([1-[(4-carbamoylcyclohexyl)carbamoyl]cyclopentyl]methyl)pentanoic acid
0.000176
-
IC50: 176 nM Canis lupus familiaris 2-([1-[(5-methyl-1,3,4-thiadiazol-2-yl)carbamoyl]cyclopentyl]methyl)pentanoic acid
0.000184
-
IC50: 184 nM Canis lupus familiaris 2-([1-[(4-butylpyridin-2-yl)carbamoyl]cyclopentyl]methyl)pentanoic acid
0.000195
-
IC50: 195 nM Canis lupus familiaris 2-[(1-[[(1R,2R)-2-benzylcyclohexyl]carbamoyl]cyclopentyl)methyl]pentanoic acid
0.000213
-
IC50: 213 nM Canis lupus familiaris 2-[(1-[[(3R)-1-carbamoylpyrrolidin-3-yl]carbamoyl]cyclopentyl)methyl]pentanoic acid
0.000237
-
IC50: 237 nM Canis lupus familiaris 3-[1-[(5-ethyl-1,3,4-thiadiazol-2-yl)carbamoyl]cyclopentyl]propanoic acid
0.000283
-
IC50: 283 nM Canis lupus familiaris 2-([1-[(5-phenyl-1,3,4-thiadiazol-2-yl)carbamoyl]cyclopentyl]methyl)pentanoic acid
0.000297
-
IC50: 297 nM Canis lupus familiaris 2-[(1-[[(1R)-3-(dimethylcarbamoyl)cyclohexyl]carbamoyl]cyclopentyl)methyl]pentanoic acid
0.000313
-
IC50: 313 nM Canis lupus familiaris 2-[[1-(2,3-dihydro-1H-inden-2-ylcarbamoyl)cyclopentyl]methyl]pentanoic acid
0.000313
-
IC50: 313 nM Canis lupus familiaris 2-([1-[(1-benzyl-6-oxo-1,6-dihydropyridin-3-yl)carbamoyl]cyclopentyl]methyl)pentanoic acid
0.00037
-
IC50: 370 nM Canis lupus familiaris 2-[(1-[[4-(dimethylcarbamoyl)cyclohexyl]carbamoyl]cyclopentyl)methyl]pentanoic acid
0.000374
-
IC50: 374 nM Canis lupus familiaris 2-([1-[(6-methoxypyridazin-3-yl)carbamoyl]cyclopentyl]methyl)pentanoic acid
0.000377
-
IC50: 377 nM Canis lupus familiaris 2-[[1-(1,3,4-thiadiazol-2-ylcarbamoyl)cyclopentyl]methyl]pentanoic acid
0.000384
-
IC50: 384 nM Canis lupus familiaris 2-([1-[(1-benzyl-2-hydroxyethyl)carbamoyl]cyclopentyl]methyl)pentanoic acid
0.00053
-
IC50: 530 nM Canis lupus familiaris 2-[(1-[[(1R)-1-phenylethyl]carbamoyl]cyclopentyl)methyl]pentanoic acid
0.0007
-
IC50: 700 nM Canis lupus familiaris 2-[(1-[[(5-methyl-1,3,4-thiadiazol-2-yl)methyl]carbamoyl]cyclopentyl)methyl]pentanoic acid
0.00089
-
IC50: 890 nM Canis lupus familiaris 2-[(1-[[(1R,2S)-2-propylcyclohexyl]carbamoyl]cyclopentyl)methyl]pentanoic acid
0.00106
-
IC50: 1060 nM Canis lupus familiaris 2-[(1-[[(3R)-1-benzylpyrrolidin-3-yl]carbamoyl]cyclopentyl)methyl]pentanoic acid
0.001139
-
IC50: 1139 nM Canis lupus familiaris 2-([1-[5-(1-benzyl-6-oxo-1,6-dihydropyridin-3-yl)-1,3,4-oxadiazol-2-yl]cyclopentyl]methyl)pentanoic acid
0.0015
-
IC50: 1500 nM Canis lupus familiaris 2-([1-[(1,3-benzodioxol-5-ylmethyl)carbamoyl]cyclopentyl]methyl)pentanoic acid
0.0015
-
IC50: 1500 nM Canis lupus familiaris 2-[[1-(pyridin-2-ylcarbamoyl)cyclopentyl]methyl]pentanoic acid
0.00171
-
IC50: 1710 nM Canis lupus familiaris 2-[(1-[[1-(hydroxymethyl)cyclopentyl]carbamoyl]cyclopentyl)methyl]pentanoic acid
0.00171
-
IC50: 1710 nM Canis lupus familiaris 2-([1-[(3-ethylpyridin-2-yl)carbamoyl]cyclopentyl]methyl)pentanoic acid
0.0031
-
IC50: 3100 nM Canis lupus familiaris 2-[[1-(5-benzyl-1,3,4-oxadiazol-2-yl)cyclopentyl]methyl]pentanoic acid