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Literature summary for 3.4.24.11 extracted from
- The metabolism of neuropeptides. Hydrolysis of peptides by the phosphoramidon-insensitive rat kidney enzyme endopeptidase-2 and by rat microvillar membranes (1988), Biochem. J., 255, 45-51.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.032 | - |
Substance P | - |
Rattus norvegicus |  |
| 0.092 | - |
bradykinin | - |
Rattus norvegicus | |
| 0.755 | - |
Luteinizing hormone-releasing hormone | - |
Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Atrial natriuretic factor + H2O | Rattus norvegicus | dominant enzyme in the hydrolysis of atrial natriuretic factor | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| angiotensin I + H2O | - |
Rattus norvegicus | ? | - |
? | |
| angiotensin II + H2O | - |
Rattus norvegicus | ? | - |
? | |
| angiotensin III + H2O | - |
Rattus norvegicus | ? | - |
? | |
| Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 + H2O | - |
Rattus norvegicus | ? | - |
? | |
| Atrial natriuretic factor + H2O | - |
Rattus norvegicus | ? | - |
? | |
| Atrial natriuretic factor + H2O | dominant enzyme in the hydrolysis of atrial natriuretic factor | Rattus norvegicus | ? | - |
? | |
| bradykinin + H2O | - |
Rattus norvegicus | ? | - |
? | |
| Luteinizing hormone-releasing hormone + H2O | - |
Rattus norvegicus | ? | - |
? | |
| oxytocin + H2O | - |
Rattus norvegicus | ? | - |
? | |
| Substance P + H2O | - |
Rattus norvegicus | ? | - |
? | |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 14 | - |
Luteinizing hormone-releasing hormone | - |
Rattus norvegicus | |
| 84.3 | - |
Substance P | - |
Rattus norvegicus | |
| 106 | - |
bradykinin | - |
Rattus norvegicus | |
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