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Literature summary for 3.4.23.B8 extracted from

  • Kuhnert, M.; Blum, A.; Steuber, H.; Diederich, W.E.
    Privileged structures meet human T-cell leukemia virus-1 (HTLV-1) C2-symmetric 3,4-disubstituted pyrrolidines as nonpeptidic HTLV-1 protease inhibitors (2015), J. Med. Chem., 58, 4845-4850 .
    View publication on PubMed
Search for more literature for 3.4.23.B8

Crystallization (Commentary)

Crystallization (Comment) Organism
purified enzyme in complex with inhibitors 9 and 10, X-ray diffraction structure determination and analysis at 2.8 A and 3.25 A resolution, respectively, modelling Human T-cell leukemia virus type I

Inhibitors

Inhibitors Comment Organism Structure
additional information structure-function relationships and binding mode analysis, detailed overview. Comparisons with HIV protease Human T-cell leukemia virus type I
N,N'-(3S,4S)-pyrrolidine-3,4-diylbis(4-amino-N-benzylbenzenesulfonamide)
-
 Human T-cell leukemia virus type I
N,N'-(3S,4S)-pyrrolidine-3,4-diylbis(N-benzyl-2-chlorobenzenesulfonamide)
-
 Human T-cell leukemia virus type I
N,N'-(3S,4S)-pyrrolidine-3,4-diylbis(N-benzyl-2-methylbenzenesulfonamide)
-
 Human T-cell leukemia virus type I
N,N'-(3S,4S)-pyrrolidine-3,4-diylbis(N-benzyl-4-nitrobenzenesulfonamide)
-
 Human T-cell leukemia virus type I
N,N'-(3S,4S)-pyrrolidine-3,4-diylbis(N-benzylbenzenesulfonamide)
-
 Human T-cell leukemia virus type I
N,N'-(3S,4S)-pyrrolidine-3,4-diylbis[N-(2-methylprop-2-en-1-yl)benzenesulfonamide]
-
 Human T-cell leukemia virus type I
N,N'-(3S,4S)-pyrrolidine-3,4-diylbis[N-(3-methylbut-2-en-1-yl)benzenesulfonamide]
-
 Human T-cell leukemia virus type I
N,N'-(3S,4S)-pyrrolidine-3,4-diylbis[N-(4-iodobenzyl)benzenesulfonamide]
-
 Human T-cell leukemia virus type I
N,N'-(3S,4S)-pyrrolidine-3,4-diylbis[N-(prop-2-en-1-yl)benzenesulfonamide]
-
 Human T-cell leukemia virus type I
N,N'-(3S,4S)-pyrrolidine-3,4-diylbis[N-[4-(trifluoromethyl)benzyl]benzenesulfonamide]
-
 Human T-cell leukemia virus type I

Organism

Organism UniProt Comment Textmining
Human T-cell leukemia virus type I
-
 HTLV-1
-

Source Tissue

Source Tissue Comment Organism Textmining

Synonyms

Synonyms Comment Organism
HTLV-1 PR
-
 Human T-cell leukemia virus type I
HTLV-1 protease
-
 Human T-cell leukemia virus type I

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000015
-
 pH and temperature not specified in the publication Human T-cell leukemia virus type I N,N'-(3S,4S)-pyrrolidine-3,4-diylbis(4-amino-N-benzylbenzenesulfonamide)
0.002
-
 pH and temperature not specified in the publication Human T-cell leukemia virus type I N,N'-(3S,4S)-pyrrolidine-3,4-diylbis(N-benzylbenzenesulfonamide)
0.0024
-
 pH and temperature not specified in the publication Human T-cell leukemia virus type I N,N'-(3S,4S)-pyrrolidine-3,4-diylbis(N-benzyl-2-chlorobenzenesulfonamide)
0.0026
-
 pH and temperature not specified in the publication Human T-cell leukemia virus type I N,N'-(3S,4S)-pyrrolidine-3,4-diylbis(N-benzyl-2-methylbenzenesulfonamide)
0.0079
-
 pH and temperature not specified in the publication Human T-cell leukemia virus type I N,N'-(3S,4S)-pyrrolidine-3,4-diylbis(N-benzyl-4-nitrobenzenesulfonamide)
0.0116
-
 pH and temperature not specified in the publication Human T-cell leukemia virus type I N,N'-(3S,4S)-pyrrolidine-3,4-diylbis[N-(3-methylbut-2-en-1-yl)benzenesulfonamide]
0.0178
-
 pH and temperature not specified in the publication Human T-cell leukemia virus type I N,N'-(3S,4S)-pyrrolidine-3,4-diylbis[N-(2-methylprop-2-en-1-yl)benzenesulfonamide]
0.1725
-
 pH and temperature not specified in the publication Human T-cell leukemia virus type I N,N'-(3S,4S)-pyrrolidine-3,4-diylbis[N-(prop-2-en-1-yl)benzenesulfonamide]
0.2
-
 pH and temperature not specified in the publication Human T-cell leukemia virus type I N,N'-(3S,4S)-pyrrolidine-3,4-diylbis[N-(4-iodobenzyl)benzenesulfonamide]
0.25
-
 pH and temperature not specified in the publication Human T-cell leukemia virus type I N,N'-(3S,4S)-pyrrolidine-3,4-diylbis[N-[4-(trifluoromethyl)benzyl]benzenesulfonamide]