Literature summary for 3.4.23.B6 extracted from

Parker, S.D.; Hunter, E.
Activation of the Mason-Pfizer monkey virus protease within immature capsids in vitro (2001), Proc. Natl. Acad. Sci. USA, 98, 14631-14636.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	proteolytic activity within the M-PMV Pr95Gag-Pro precursor is effectively suppressed within an assembled immature capsid, but with addition of dithiothreitol, there is a dramatic increase in protease activity. The activation of the protease results in the cleavage of p17 from the Pr95 precursor as a primary event, followed by processing of the Gag polyproteins into other mature viral proteins	Mason-Pfizer monkey virus

Organism

Organism	UniProt	Comment	Textmining
Mason-Pfizer monkey virus	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
proteolytic modification	proteolytic activity within the M-PMV Pr95Gag-Pro precursor is effectively suppressed within an assembled immature capsid, but with addition of dithiothreitol, there is a dramatic increase in protease activity. The activation of the protease results in the cleavage of p17 from the Pr95 precursor as a primary event, followed by processing of the gag polyproteins into other mature viral proteins	Mason-Pfizer monkey virus

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Release 2023.1 (January 2023)