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Literature summary for 3.4.23.B5 extracted from

  • Loeving, R.; Wu, S.R.; Sjoeberg, M.; Lindqvist, B.; Garoff, H.
    Maturation cleavage of the murine leukemia virus Env precursor separates the transmembrane subunits to prime it for receptor triggering (2012), Proc. Natl. Acad. Sci. USA, 109, 7735-7740.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
murine leukemia virus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
R-peptide precursor Env + H2O
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murine leukemia virus ? the viral protease removes a 16-residue peptide, the R-peptide from the endodomain of the transmembrane subunit. The legs of the R-peptide Env are held together by trimeric interactions at the very bottom of Env. It is the transmembrane leg separation, normally caused by R-peptide cleavage, that primes Env for receptor triggering ?