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Literature summary for 3.4.23.B5 extracted from
- The MuLV 4070A G541R Env mutation decreases the stability and alters the conformation of the TM ectodomain (2008), Virology, 371, 165-174.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| tansmembrane ectodomain of of MuLV is expressed as a His-tagged fusion protein in Escherichia coli | Moloney murine leukemia virus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| G541R | size exclusion chromatography shows that the multimerization properties are similar among expressed wild-type and mutant ectodomain peptides. Circular dichroism measurements reveal decreased thermal stability of the G541R mutant as compared to wild-type. The G541R mutant also renders the peptide more susceptible to Lys-C protease cleavage. A monoclonal antibody does not bind to the G541R mutant peptide, suggesting a structural difference from wild-type | Moloney murine leukemia virus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Moloney murine leukemia virus | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MuLV 4070A | - |
Moloney murine leukemia virus |
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Release 2023.1 (January 2023)
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