Literature summary for 3.4.23.B4 extracted from

Qian, X.; Moris-Varas, F.; Fitzgerald, M.C.; Wong, C.H.
C2-symmetrical tetrahydroxyazepanes as inhibitors of glycosidases and HIV/FIV proteases (1996), Bioorg. Med. Chem., 4, 2055-2069.

Search for more literature for 3.4.23.B4

Inhibitors

Inhibitors	Comment	Organism	Structure
(3S,4R,5R,6S)-3,4-di-O-(3'-fluorobenzyl)-N-methyl-3,4,5,6-tetrahydroxyazepane N-oxide	weak	feline immunodeficiency virus
(3S,4R,5R,6S)-3,6-di-O-(3',5'-difluorobenzyl)-3,4,5,6-tetrahydroxyazepane	IC50: 0.67 mM	feline immunodeficiency virus
(3S,4R,5R,6S)-3,6-di-O-(3'-fluorobenzyl)-3,4,5,6-tetrahydroxyazepane	IC50: 1.4 mM	feline immunodeficiency virus

Organism

Organism	UniProt	Comment	Textmining
feline immunodeficiency virus	-	-	-

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.67	-	IC50: 0.67 mM	feline immunodeficiency virus	(3S,4R,5R,6S)-3,6-di-O-(3',5'-difluorobenzyl)-3,4,5,6-tetrahydroxyazepane
1.4	-	IC50: 1.4 mM	feline immunodeficiency virus	(3S,4R,5R,6S)-3,6-di-O-(3'-fluorobenzyl)-3,4,5,6-tetrahydroxyazepane

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Release 2023.1 (January 2023)