Literature summary for 3.4.23.B2 extracted from

Rose, R.B.; Rose, J.R.; Salto, R.; Craik, C.S.; Stroud, R.M.
Structure of the protease from simian immunodeficiency virus: complex with an irreversible nonpeptide inhibitor (1993), Biochemistry, 32, 12498-12507.

Search for more literature for 3.4.23.B2

Crystallization (Commentary)

Crystallization (Comment)	Organism
enzyme covalently bound to the inhibitor 1,2-epoxy-3-(p-nitrophenoxy)propane. Crystals of the variant SIV PR S4H appear to have the same morphology as those obtained from wild-type enzyme	Simian immunodeficiency virus

Protein Variants

Protein Variants	Comment	Organism
S4H	mutation does not significantly affect the kinetic parameters of the enzyme but stabilizes it approximately 4fold to autolysis. Crystals of the variant SIV PR S4H appear to have the same morphology as those obtained from wild-type enzyme	Simian immunodeficiency virus

Inhibitors

Inhibitors	Comment	Organism	Structure
1,2-epoxy-3-(4-nitrophenoxy)propane	half-maximal inactivation rate at 8.04 mM; i.e. EPNP	Simian immunodeficiency virus

Organism

Organism	UniProt	Comment	Textmining
Simian immunodeficiency virus	-	-	-

pI Value

Organism	Comment	pI Value Maximum	pI Value
Simian immunodeficiency virus	calculation with the program PREDICT	-	5.1

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)