Literature summary for 3.4.23.B10 extracted from

Cameron, C.E.; Burstein, H.; Bizub-Bender, D.; Ridky, T.; Weber, I.T.; Wlodawer, A.; Skalka, A.M.; Leis, J.
Identification of amino acid residues of the retroviral aspartic proteinases important for substrate specificity and catalytic efficiency (1995), Adv. Exp. Med. Biol., 362, 399-406.

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Protein Variants

Protein Variants	Comment	Organism
A100L	less than 1% of the activity relative to wild-type enzyme with PPAVSLAMTMRR	Rous sarcoma virus
DELTAN61-Q63	245% of the activity relative to wild-type enzyme with PPAVSLAMTMRR	Rous sarcoma virus
I42D	62% of the activity relative to wild-type enzyme with PPAVSLAMTMRR	Rous sarcoma virus
I44V	211% of the activity relative to wild-type enzyme with PPAVSLAMTMRR	Rous sarcoma virus
M73V	31% of the activity relative to wild-type enzyme with PPAVSLAMTMRR	Rous sarcoma virus
M73V/A100L	96% of the activity relative to wild-type enzyme with PPAVSLAMTMRR	Rous sarcoma virus
Q63M	448% of the activity relative to wild-type enzyme with PPAVSLAMTMRR	Rous sarcoma virus
S107N	377% of the activity relative to wild-type enzyme with PPAVSLAMTMRR	Rous sarcoma virus
S38T	200% of the activity relative to wild-type enzyme with PPAVSLAMTMRR	Rous sarcoma virus
V104T	229% of the activity relative to wild-type enzyme with PPAVSLAMTMRR	Rous sarcoma virus

Organism

Organism	UniProt	Comment	Textmining
Rous sarcoma virus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
PPAVSLAMTMRR + H2O	-	Rous sarcoma virus	PPAVS + LAMTMRR	-	?

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Release 2023.1 (January 2023)