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Literature summary for 3.4.23.5 extracted from

  • Xiao, R.; Zhang, Z.; Wang, H.; Han, Y.; Gou, M.; Li, B.; Duan, D.; Wang, J.; Liu, X.; Li, Q.
    Identification and characterization of a cathepsin D homologue from lampreys (Lampetra japonica) (2015), Dev. Comp. Immunol., 49, 149-156.
    View publication on PubMed
Search for more literature for 3.4.23.5

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HEK-293 cells Lethenteron camtschaticum

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
 Lethenteron camtschaticum 5764
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
42772
-
 x * 42772, calculated from amino acid sequence Lethenteron camtschaticum

Organism

Organism UniProt Comment Textmining
Lethenteron camtschaticum A0A0A7HF39 Japanese lamprey
-

Purification (Commentary)

Purification (Comment) Organism
ANTI-FLAG M2 affinity resin column chromatography, and gel filtration Lethenteron camtschaticum

Source Tissue

Source Tissue Comment Organism Textmining
buccal gland highest expression Lethenteron camtschaticum
-
gill
-
 Lethenteron camtschaticum
-
heart
-
 Lethenteron camtschaticum
-
immune system
-
 Lethenteron camtschaticum
-
intestine
-
 Lethenteron camtschaticum
-
kidney
-
 Lethenteron camtschaticum
-
liver
-
 Lethenteron camtschaticum
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Fibrinogen + H2O the Aalpha and Bbeta chains of fibrinogen are digested completely, and the gamma chain is degraded partly Lethenteron camtschaticum ?
-
 ?
Hemoglobin + H2O
-
 Lethenteron camtschaticum ?
-
 ?
serum albumin + H2O
-
 Lethenteron camtschaticum ?
-
 ?

Subunits

Subunits Comment Organism
? x * 42772, calculated from amino acid sequence Lethenteron camtschaticum

Synonyms

Synonyms Comment Organism
CatD
-
 Lethenteron camtschaticum

pI Value

Organism Comment pI Value Maximum pI Value
Lethenteron camtschaticum calculated from amino acid sequence
-
 6.2

Expression

Organism Comment Expression
Lethenteron camtschaticum cathepsin D expression in the buccal gland is increased 6.5-8.5fold after challenge with Escherichia coli or Staphylococcus aureus up

General Information

General Information Comment Organism
physiological function cathepsin D plays key roles in immune response to exogenous pathogens and also acts as a digestive enzyme during the adaptation to a blood-feeding lifestyle Lethenteron camtschaticum