Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
extracellular | - |
Homo sapiens | - |
- |
lysosome | - |
Homo sapiens | 5764 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
14000 | - |
1 * 34000 + 1 * 14000, mature enzyme, SDS-PAGE | Homo sapiens |
34000 | - |
1 * 34000 + 1 * 14000, mature enzyme, SDS-PAGE | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Hemoglobin + H2O | Homo sapiens | - |
? | - |
? | |
additional information | Homo sapiens | Man-6PR, prosaposin, ceramide, low-density lipoprotein receptor-related protein-1, maspin, sortilin, and cystatin C are cathespin D binding partner | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P07339 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | the enzyme is glycosylated at two N-linked glycosylation sites (Asn residues 134 and 263) | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
MCF-7 cell | - |
Homo sapiens | - |
MDA-MB-231 cell | - |
Homo sapiens | - |
MDA-MB231 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Albumin + H2O | - |
Homo sapiens | ? | - |
? | |
Hemoglobin + H2O | - |
Homo sapiens | ? | - |
? | |
additional information | Man-6PR, prosaposin, ceramide, low-density lipoprotein receptor-related protein-1, maspin, sortilin, and cystatin C are cathespin D binding partner | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
heterodimer | 1 * 34000 + 1 * 14000, mature enzyme, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
CatD | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | epidermal growth factor rapidly induces enzyme mRNA by 2-4fold. Cathepsin D is overexpressed in breast cancer | up |