Literature summary for 3.4.23.5 extracted from

Conus, S.; Perozzo, R.; Reinheckel, T.; Peters, C.; Scapozza, L.; Yousefi, S.; Simon, H.U.
Caspase-8 is activated by cathepsin D initiating neutrophil apoptosis during the resolution of inflammation (2008), J. Exp. Med., 205, 685-698.

Search for more literature for 3.4.23.5

Application

Application	Comment	Organism
medicine	a new proapoptotic pathway is shown in which caspase-8 is activated by cathepsin D initiating neutrophil apoptosis during the resolution of inflammation	Mus musculus
medicine	a new proapoptotic pathway is shown in which caspase-8 is activated by cathepsin D initiating neutrophil apoptosis during the resolution of inflammation	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	cathepsin deficient mice show a delayed caspase activation and reduced neutrophil apoptosis. Furthermore, cathepsin D deficiency prolongs innate immune responses in experimental bacterial infection and in septic shock	Mus musculus

Inhibitors

Inhibitors	Comment	Organism	Structure
pepstatin A	inhibition of cathepsin D results in delayed caspase activation and reduced neutrophil apoptosis	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
azurophil granule	cathepsin D is released from azurophilic granules in neutrophils in a caspase-independent but reactive oxygen species-dependent manner. Under inflammatory conditions the translocation of cathepsin D in the cytosol is blocked	Homo sapiens	42582	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
neutrophil	studies are carried out using peripheral blood neutrophils which are purified from healthy normal individuals and patients suffering from septic shock by Ficoll-Hypaque centrifugation	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
((7-methoxycoumarin-4-yl)acetyl-Pro-Leu-Gly-Leu-N-3-(2,4-dinitro-phenyl)-L-2,3-diaminopropionyl-Ala-Arg-NH2) + H2O	-	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
cathepsin D	-	Mus musculus
cathepsin D	-	Homo sapiens

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Release 2023.1 (January 2023)