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Literature summary for 3.4.23.5 extracted from
- Cathepsin D cleaves aggrecan at unique sites within the interglobular domain and chondroitin sulfate attachment regions that are also cleaved when cartilage is maintained at acid pH (2001), Matrix Biol., 20, 543-553.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| bovine aggrecan + H2O | cleavage at five sites within the core protein, no preferential cleqavage at any one site | Bos taurus | ? | - |
? |  |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 5.2 | 6.5 | cleavage of bovine aggrecan, within this range, no change in products | Bos taurus |
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Release 2023.1 (January 2023)
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