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Literature summary for 3.4.23.5 extracted from

  • Woessner, J.F.; Shamberger, R.J.
    Purification and properties of cathepsin D from bovine uterus (1971), J. Biol. Chem., 246, 1951-1960.
    View publication on PubMed

General Stability

General Stability Organism
not completely stable to freezing. If freezing is followed by lyophilization, 35% loss of activity Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
(NH4)2SO4
-
Bos taurus
3-p-hydroxyphenylpyruvate
-
Bos taurus
dithiothreitol
-
Bos taurus
Fe3+ FeCl3 Bos taurus
Hg2+ Hg(NO3)2 Bos taurus
KCl
-
Bos taurus
Pb2+ Pb(NO3)2 Bos taurus
Urea
-
Bos taurus
Vitamin A
-
Bos taurus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
43000
-
gel filtration Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
uterus
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Hemoglobin + H2O denatured hemoglobin Bos taurus ?
-
?
insulin + H2O B-chain, major points of cleavage: Leu15-Tyr16, Phe24-Phe25, Phe25-Tyr26. Additional points of cleavage: Phe1-Val2, Glu13-Ala14, Ala14-leu15, Tyr16-Leu17 Bos taurus ?
-
?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
60
-
pH 6.3, rapid loss of activity Bos taurus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
3.2
-
hemoglobin Bos taurus
4.2
-
urea-denatured hemoglobin Bos taurus

pH Stability

pH Stability pH Stability Maximum Comment Organism
5 7 maximal stability Bos taurus