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Literature summary for 3.4.23.49 extracted from

  • Tagai, C.; Morita, S.; Shiraishi, T.; Miyaji, K.; Iwamuro, S.
    Antimicrobial properties of arginine- and lysine-rich histones and involvement of bacterial outer membrane protease T in their differential mode of actions (2011), Peptides, 32, 2003-2009.
    View publication on PubMed
Search for more literature for 3.4.23.49

Inhibitors

Inhibitors Comment Organism Structure
calf thymus histone H2B growth inhibitory activity against bacterial gene expressing Escherichia coli with calculated 50% growth inhibitory concentrations of 3.8 microM. Histone H2B penetrates the cell membrane of JCM5491 OmpT+ cells Escherichia coli
calf thymus histone H3 growth inhibitory activity against bacterial gene expressing Escherichia coli with calculated 50% growth inhibitory concentrations of 10 microM. Histones H3 and H4 remain on the cell surface and subsequently disrupt the cell membrane structure with bleb formation in a manner similar to general antimicrobial peptides Escherichia coli
calf thymus histone H4 growth inhibitory activity against bacterial gene expressing Escherichia coli with calculated 50% growth inhibitory concentrations of 12.7 microM. Histones H3 and H4 remain on the cell surface and subsequently disrupt the cell membrane structure with bleb formation in a manner similar to general antimicrobial peptides Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Escherichia coli JCM 5491
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
calf thymus histone H2B + H2o
-
 Escherichia coli ? strong fragmentation of histone H2B ?
calf thymus histone H2B + H2o
-
 Escherichia coli JCM 5491 ? strong fragmentation of histone H2B ?
calf thymus histone H3 + H2o
-
 Escherichia coli ? moderate fragmentation of histone H3 ?
calf thymus histone H3 + H2o
-
 Escherichia coli JCM 5491 ? moderate fragmentation of histone H3 ?
calf thymus histone H4 + H2o
-
 Escherichia coli ? slight fragmentation of histone H4 ?
calf thymus histone H4 + H2o
-
 Escherichia coli JCM 5491 ? slight fragmentation of histone H4 ?

General Information

General Information Comment Organism
physiological function OmpT is involved in the antimicrobial properties of Arg- and Lys-rich histones and the modes of antimicrobial action of these histones are different Escherichia coli