Application | Comment | Organism |
---|---|---|
medicine | the different contributions of EHEC and EPEC strains OmpT to the degradation and inactivation of antimicrobial peptide LL-37 may be due to their adaptation to their respective niches within the host, the colon and small intestine, respectively, where the environmental cues and abundance of antimicrobial peptides are different | Escherichia coli |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
enterohemorrhagic Escherichia coli, EHEC | - |
Escherichia coli | - |
enteropathogenic Escherichia coli, EPEC | - |
Escherichia coli EHEC O157:H7 | - |
enterohemorrhagic Escherichia coli, EHEC | - |
Escherichia coli EPEC / E2348/69 | - |
enteropathogenic Escherichia coli, EPEC | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-aminobenzoyl-SLGRKIQI-K(N6-2,4-dinitrophenyl)-NH2 + H2O | FRET-substrate, derived from the protein C2 of the classical complement pathway | Escherichia coli | 2-aminobenzoyl-SLGR + KIQI-K(N6-2,4-dinitrophenyl)-NH2 | - |
? | |
2-aminobenzoyl-SLGRKIQI-K(N6-2,4-dinitrophenyl)-NH2 + H2O | FRET-substrate, derived from the protein C2 of the classical complement pathway. Poor substrate | Escherichia coli | 2-aminobenzoyl-SLGR + KIQI-K(N6-2,4-dinitrophenyl)-NH2 | - |
? | |
2-aminobenzoyl-SLGRKIQI-K(N6-2,4-dinitrophenyl)-NH2 + H2O | FRET-substrate, derived from the protein C2 of the classical complement pathway | Escherichia coli EHEC O157:H7 | 2-aminobenzoyl-SLGR + KIQI-K(N6-2,4-dinitrophenyl)-NH2 | - |
? | |
2-aminobenzoyl-SLGRKIQI-K(N6-2,4-dinitrophenyl)-NH2 + H2O | FRET-substrate, derived from the protein C2 of the classical complement pathway. Poor substrate | Escherichia coli EHEC O157:H7 | 2-aminobenzoyl-SLGR + KIQI-K(N6-2,4-dinitrophenyl)-NH2 | - |
? | |
2-aminobenzoyl-SLGRKIQI-K(N6-2,4-dinitrophenyl)-NH2 + H2O | FRET-substrate, derived from the protein C2 of the classical complement pathway | Escherichia coli EPEC / E2348/69 | 2-aminobenzoyl-SLGR + KIQI-K(N6-2,4-dinitrophenyl)-NH2 | - |
? | |
2-aminobenzoyl-SLGRKIQI-K(N6-2,4-dinitrophenyl)-NH2 + H2O | FRET-substrate, derived from the protein C2 of the classical complement pathway. Poor substrate | Escherichia coli EPEC / E2348/69 | 2-aminobenzoyl-SLGR + KIQI-K(N6-2,4-dinitrophenyl)-NH2 | - |
? | |
C18G + H2O | synthetic alpha-helical peptide, whose sequence has been optimized for maximal antibacterial activity | Escherichia coli | ? | - |
? | |
C18G + H2O | synthetic alpha-helical peptide, whose sequence has been optimized for maximal antibacterial activity | Escherichia coli EHEC O157:H7 | ? | - |
? | |
C18G + H2O | synthetic alpha-helical peptide, whose sequence has been optimized for maximal antibacterial activity | Escherichia coli EPEC / E2348/69 | ? | - |
? | |
LL-37 + H2O | human antimicrobial peptide of the cathelicidin family, cleavage occurs at dibasic sites | Escherichia coli | ? | - |
? | |
LL-37 + H2O | human antimicrobial peptide of the cathelicidin family, cleavage occurs at dibasic sites | Escherichia coli EHEC O157:H7 | ? | - |
? | |
LL-37 + H2O | human antimicrobial peptide of the cathelicidin family, cleavage occurs at dibasic sites | Escherichia coli EPEC / E2348/69 | ? | - |
? |
Organism | Comment | Expression |
---|---|---|
Escherichia coli | expression of the ompT gene is higher in EHEC strains than in EPEC strains | additional information |
General Information | Comment | Organism |
---|---|---|
physiological function | deletion mutant is more susceptible to alpha-helical antimicrobial peptides | Escherichia coli |