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Literature summary for 3.4.23.49 extracted from

  • Yun, T.; Cott, J.; Tapping, R.; Slauch, J.; Morrissey, J.
    Proteolytic inactivation of tissue factor pathway inhibitor by bacterial omptins (2009), Blood, 113, 1139-1148.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.23.49

Organism

Organism UniProt Comment Textmining
Escherichia coli
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-
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Salmonella enterica
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-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
human tissue factor pathway inhibitor + H2O it is hypothesized that TFPI evolved sensitivity to proteolytic inactivation by bacterial omptins to potentiate procoagulant responses to bacterial infection which may contribute to the hemostatic imbalance in disseminated intravascular coagulation and other coagulopathies accompanying severe sepsis Escherichia coli ?
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 ?
human tissue factor pathway inhibitor + H2O it is hypothesized that TFPI evolved sensitivity to proteolytic inactivation by bacterial omptins to potentiate procoagulant responses to bacterial infection which may contribute to the hemostatic imbalance in disseminated intravascular coagulation and other coagulopathies accompanying severe sepsis Salmonella enterica ?
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 ?

Synonyms

Synonyms Comment Organism
ompT
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 Escherichia coli
ompT
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 Salmonella enterica

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Escherichia coli
37
-
 assay at Salmonella enterica

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Escherichia coli
7.4
-
 assay at Salmonella enterica

General Information

General Information Comment Organism
malfunction using gene deletions, it is demonstrated that bacterial inactivation of tissue factor pathway inhibitor (TFPI) requires omptin expression Escherichia coli
malfunction using gene deletions, it is demonstrated that bacterial inactivation of tissue factor pathway inhibitor (TFPI) requires omptin expression Salmonella enterica