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Literature summary for 3.4.23.48 extracted from

  • van Lier, C.J.; Tiner, B.L.; Chauhan, S.; Motin, V.L.; Fitts, E.C.; Huante, M.B.; Endsley, J.J.; Ponnusamy, D.; Sha, J.; Chopra, A.K.
    Further characterization of a highly attenuated Yersinia pestis CO92 mutant deleted for the genes encoding Braun lipoprotein and plasminogen activator protease in murine alveolar and primary human macrophages (2015), Microb. Pathog., 80, 27-38.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine the Lpp Pla double mutant of Yersinia pestis CO92 is highly attenuated and it retains the ability to elicit innate and subsequent acquired immune responses in the host similar to that of wild-type CO92, which are highly desirable in a live-attenuated vaccine candidate Yersinia pestis

Organism

Organism UniProt Comment Textmining
Yersinia pestis
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General Information

General Information Comment Organism
physiological function the plasminogen activator Pla single and the Braun lipoprotein Lpp Pla double mutant are unable to survive efficiently in murine and human macrophages. The levels of Pla and its associated protease activity are not affected in the Lpp single mutant, and, likewise, deletion of the Pla gene from wild-type does not alter Lpp levels. The ability of the Lpp Pla double mutant to be phagocytized by macrophages, to stimulate production of tumor necrosis factor-alpha and interleukin-6, and to activate the nitric oxide killing pathways of the host cells remains unaltered when compared to the wild-type-infected macrophages. Macrophages infected with either the wild-type or the Lpp Pla double mutant are equally efficient in their uptake of zymosan particles Yersinia pestis