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Literature summary for 3.4.23.48 extracted from

  • Haiko, J.; Kukkonen, M.; Ravantti, J.J.; Westerlund-Wikstroem, B.; Korhonen, T.K.
    The single substitution I259T, conserved in the plasminogen activator Pla of pandemic Yersinia pestis branches, enhances fibrinolytic activity (2009), J. Bacteriol., 191, 4758-4766.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.23.48

Cloned(Commentary)

Cloned (Comment) Organism
the mutant enzyme T259I is expressed in Escherichia coli XL1 Blue cells and in Yersinia pestis strain KIM D34 Yersinia pestis

Protein Variants

Protein Variants Comment Organism
T259I the substitution impairs fibrinolytic activity and plasminogen activation Yersinia pestis

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane outer membrane Yersinia pestis 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
alpha2-antiplasmin + H2O Yersinia pestis Pla inactivates alpha2-antiplasmin ?
-
 ?
plasminogen + H2O Yersinia pestis
-
 plasmin + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Yersinia pestis
-
 lineages Microtus and Angola
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alpha2-antiplasmin + H2O Pla inactivates alpha2-antiplasmin Yersinia pestis ?
-
 ?
plasminogen + H2O
-
 Yersinia pestis plasmin + ?
-
 ?

Synonyms

Synonyms Comment Organism
beta-Pla
-
 Yersinia pestis
Pla
-
 Yersinia pestis

General Information

General Information Comment Organism
physiological function the outer membrane plasminogen activator Pla of Yersinia pestis is a central virulence factor in plague Yersinia pestis