Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Yersinia pestis |
Protein Variants | Comment | Organism |
---|---|---|
D206A | proteolytic activity is abolished | Yersinia pestis |
S99A | proteolytic activity is abolished | Yersinia pestis |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
outer membrane | - |
Yersinia pestis | 19867 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
plasminogen + H2O | Yersinia pestis | Pla belongs to the omptin family of enterobacterial surface proteases and is responsible for the highly efficient invasion of the plague bacterium from the subcutaneous infection site into the circulation | plasmin + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Yersinia pestis | - |
Pla mediates bacterial invasion into human endothelial cells independently of its proteolytic activity | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
plasminogen + H2O | Pla belongs to the omptin family of enterobacterial surface proteases and is responsible for the highly efficient invasion of the plague bacterium from the subcutaneous infection site into the circulation | Yersinia pestis | plasmin + ? | - |
? |