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Literature summary for 3.4.23.47 extracted from

  • Wu, J.C.; Carr, S.F.; Jarnagin, K.; Kirsher, S.; Barnett, J.; Chow, J.; Chan, H.W.; Chen, M.S.; Medzihradszky, D.; Yamashiro, D.; et al.
    Synthetic HIV-2 protease cleaves the GAG precursor of HIV-1 with the same specificity as HIV-1 protease (1990), Arch. Biochem. Biophys., 277, 306-311.
    View publication on PubMed

Application

Application Comment Organism
medicine potential target for chemotherapy of virus infection and associated diseases, essential for maturation of infectious virions, development of drugs against the protease should be effective against HIV-2 Human immunodeficiency virus 2

Inhibitors

Inhibitors Comment Organism Structure
additional information no inhibition with 1,10-phenanthroline and phenylmethylsulfonylfluoride or EDTA Human immunodeficiency virus 2
pepstatin A
-
Human immunodeficiency virus 2

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GAG precursor protein of HIV-2 + H2O Human immunodeficiency virus 2
-
?
-
?

Organism

Organism UniProt Comment Textmining
Human immunodeficiency virus 2
-
human immunodeficiency virus type 2
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GAG precursor protein F16 of HIV-1 + H2O chemically synthesized aspartyl protease enzyme catalyzes specific processing of the recombinant 43-kDa protein Human immunodeficiency virus 2 ?
-
?
GAG precursor protein of HIV-2 + H2O
-
Human immunodeficiency virus 2 ?
-
?