Application | Comment | Organism |
---|---|---|
analysis | development and validation of novel plasma BACE activity, soluble amyloid precursor proteins alpha and beta assays. Plasma BACE activity assay is sensitive and specific | Homo sapiens |
medicine | BACE1 but not gamma-secretase inhibition leads to significant lowering of plasma soluble amyloid precursor protein beta with concurrent elevation of plasma soluble amyloid precursor protein alpha. Alzheimer's disease subjects show a significant increase in plasma BACE1 activity, soluble amyloid precursor proteins alpha and beta, and amyloid beta42 compared with age-matched controls | Macaca mulatta |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Macaca mulatta | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
plasma | - |
Homo sapiens | - |
plasma | - |
Macaca mulatta | - |