Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.23.46 extracted from

  • Wu, G.; Sankaranarayanan, S.; Wong, J.; Tugusheva, K.; Michener, M.S.; Shi, X.; Cook, J.J.; Simon, A.J.; Savage, M.J.
    Characterization of plasma beta-secretase (BACE1) activity and soluble amyloid precursor proteins as potential biomarkers for Alzheimer's disease (2012), J. Neurosci. Res., 90, 2247-2258.
    View publication on PubMed

Application

Application Comment Organism
analysis development and validation of novel plasma BACE activity, soluble amyloid precursor proteins alpha and beta assays. Plasma BACE activity assay is sensitive and specific Homo sapiens
medicine BACE1 but not gamma-secretase inhibition leads to significant lowering of plasma soluble amyloid precursor protein beta with concurrent elevation of plasma soluble amyloid precursor protein alpha. Alzheimer's disease subjects show a significant increase in plasma BACE1 activity, soluble amyloid precursor proteins alpha and beta, and amyloid beta42 compared with age-matched controls Macaca mulatta

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Macaca mulatta
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
plasma
-
Homo sapiens
-
plasma
-
Macaca mulatta
-