Literature summary for 3.4.23.46 extracted from

Thomas, A.A.; Hunt, K.W.; Newhouse, B.; Watts, R.J.; Liu, X.; Vigers, G.; Smith, D.; Rhodes, S.P.; Brown, K.D.; Otten, J.N.; Burkard, M.; Cox, A.A.; Geck Do, M.K.; Dutcher, D.; Rana, S.; DeLisle, R.K.; Regal, K.; Wright, A.D.; Groneberg, R.; Liao, J.; Scearce-Levie, K.; Siu, M.; Purkey, H.E.; Lyssikatos, J.P.
8-Tetrahydropyran-2-yl chromans: highly selective beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors (2014), J. Med. Chem., 57, 10112-10129.

Cloned(Commentary)

Cloned (Comment)	Organism
expression in CHO cells	Homo sapiens

Inhibitors	Comment	Organism	Structure
(4aS,4'S,10aR)-8-(2-fluoropyridin-3-yl)-4a-methyl-3,4,4a,10a-tetrahydro-2H,5'H-spiro[pyrano[3,2-b]chromene-10,4'-thiazol]-2'-amine	compound demonstrates a 69% reduction in rat cerebrospinal fluid amyloid beta1?40 at 60 mg/kg	Homo sapiens

Organism	UniProt	Comment	Textmining
Homo sapiens	P56817	-	-

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.000045	-	pH 4.4, 22°C	Homo sapiens	(4aS,4'S,10aR)-8-(2-fluoropyridin-3-yl)-4a-methyl-3,4,4a,10a-tetrahydro-2H,5'H-spiro[pyrano[3,2-b]chromene-10,4'-thiazol]-2'-amine

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Release 2023.1 (January 2023)