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Literature summary for 3.4.23.46 extracted from

  • Burgos, P.V.; Mardones, G.A.; Rojas, A.L.; daSilva, L.L.; Prabhu, Y.; Hurley, J.H.; Bonifacino, J.S.
    Sorting of the Alzheimer’s disease amyloid precursor protein mediated by the AP-4 complex (2010), Dev. Cell, 18, 425-436.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
amyloid precursor protein + H2O Homo sapiens amyloid precursor protein is cleaved at the N-terminus of Abeta by beta-secretase yielding a slightly shorter soluble APPbeta fragment and a slightly longer CTFbeta fragment (also termed C99) fragments of amyloid precursor protein
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?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
amyloid precursor protein + H2O amyloid precursor protein is cleaved at the N-terminus of Abeta by beta-secretase yielding a slightly shorter soluble APPbeta fragment and a slightly longer CTFbeta fragment (also termed C99) Homo sapiens fragments of amyloid precursor protein
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?

Synonyms

Synonyms Comment Organism
BACE1
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Homo sapiens
beta-secretase
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Homo sapiens

Expression

Organism Comment Expression
Homo sapiens depletion of mu4 by RNAi does not alter the distribution of beta-secretase (BACE1) additional information