Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
amyloid precursor protein + H2O | Homo sapiens | - |
fragments of amyloid precursor protein | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
7-amido-4-methylcoumarin-SEVNLDAEFRK-(2,4-dinitrophenyl)-RR-NH2 + H2O | - |
Homo sapiens | ? | - |
? | |
amyloid precursor protein + H2O | - |
Homo sapiens | fragments of amyloid precursor protein | - |
? |
Synonyms | Comment | Organism |
---|---|---|
BACE-1 | - |
Homo sapiens |
beta-secretase | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | BACE-1 activity correlates inversely with total soluble and oligomeric Abeta1-42 | down |
Homo sapiens | no correlation is observed between BACE-1 activity and NEP protein level | additional information |
Homo sapiens | BACE-1 activity correlates closely with age in controls and is significantly higher in Alzheimer's disease. BACE-1 activity correlates with total insoluble Abeta | up |