Any feedback?
Literature summary for 3.4.23.46 extracted from
- Biotransformation of isoimperatorin and imperatorin by Glomerella cingulata and beta-secretase inhibitory activity (2010), Bioorg. Med. Chem., 18, 455-459.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 6,7-furano-5-prenyloxy hydrocoumaric acid | - |
Homo sapiens |  |
| 6,7-furano-5-prenyloxy hydrocoumaric acid methyl ester | - |
Homo sapiens | |
| 6,7-furano-8a-methoxy-5-prenyloxy hydrocoumaric acid | - |
Homo sapiens | |
| 6,7-furano-8a-methoxy-5-prenyloxy hydrocoumaric acid methyl ester | competitive-type inhibitor | Homo sapiens | |
| imperatorin | - |
Homo sapiens | |
| isoimperatorin | - |
Homo sapiens | |
| additional information | not inhibited by xanthoxol | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Rh-EVNLDAEFK-quencher + H2O | - |
Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| BACE1 | - |
Homo sapiens |
| beta-secretase | - |
Homo sapiens |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0113 | - |
6,7-furano-8a-methoxy-5-prenyloxy hydrocoumaric acid methyl ester | in 50 mM sodium acetate, pH 4.5, at 25°C | Homo sapiens | |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.0162 | - |
in 50 mM sodium acetate, pH 4.5, at 25°C | Homo sapiens | 6,7-furano-8a-methoxy-5-prenyloxy hydrocoumaric acid methyl ester | |
| 0.0305 | - |
in 50 mM sodium acetate, pH 4.5, at 25°C | Homo sapiens | 6,7-furano-5-prenyloxy hydrocoumaric acid methyl ester | |
| 0.0918 | - |
in 50 mM sodium acetate, pH 4.5, at 25°C | Homo sapiens | imperatorin | |
| 0.1856 | - |
in 50 mM sodium acetate, pH 4.5, at 25°C | Homo sapiens | 6,7-furano-5-prenyloxy hydrocoumaric acid | |
| 0.2033 | - |
in 50 mM sodium acetate, pH 4.5, at 25°C | Homo sapiens | 6,7-furano-8a-methoxy-5-prenyloxy hydrocoumaric acid | |
| 0.2442 | - |
in 50 mM sodium acetate, pH 4.5, at 25°C | Homo sapiens | isoimperatorin | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
