Inhibitors | Comment | Organism | Structure |
---|---|---|---|
7-phloroethol | significant BACE1 inhibition in a dose-dependent manner | Homo sapiens | |
dieckol | significant BACE1 inhibition in a dose-dependent manner | Homo sapiens | |
dioxinodehydroeckol | significant BACE1 inhibition in a dose-dependent manner | Homo sapiens | |
eckol | significant BACE1 inhibition in a dose-dependent manner | Homo sapiens | |
phlorofurofucoeckol-A | significant BACE1 inhibition in a dose-dependent manner | Homo sapiens | |
phloroglucinol | significant BACE1 inhibition in a dose-dependent manner | Homo sapiens | |
quercetin | significant BACE1 inhibition in a dose-dependent manner | Homo sapiens | |
triphloroethol A | significant BACE1 inhibition in a dose-dependent manner | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
amyloid precursor protein + H2O | Homo sapiens | - |
fragments of amyloid precursor protein | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
amyloid precursor protein + H2O | - |
Homo sapiens | fragments of amyloid precursor protein | - |
? | |
rhodamine-EVNLDAEFK-quencher + H2O | - |
Homo sapiens | rhodamine-EVNL + DAEFK-quencher | - |
? |
Synonyms | Comment | Organism |
---|---|---|
BACE1 | - |
Homo sapiens |
beta-secretase | - |
Homo sapiens |
beta-site amyloid precursor protein cleaving enzyme | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00213 | - |
in 50 mM sodium acetate, pH 4.5, at 25°C | Homo sapiens | phlorofurofucoeckol-A | |
0.00221 | - |
in 50 mM sodium acetate, pH 4.5, at 25°C | Homo sapiens | dieckol | |
0.00535 | - |
in 50 mM sodium acetate, pH 4.5, at 25°C | Homo sapiens | dioxinodehydroeckol | |
0.00859 | - |
in 50 mM sodium acetate, pH 4.5, at 25°C | Homo sapiens | 7-phloroethol | |
0.01082 | - |
in 50 mM sodium acetate, pH 4.5, at 25°C | Homo sapiens | quercetin | |
0.01168 | - |
in 50 mM sodium acetate, pH 4.5, at 25°C | Homo sapiens | triphloroethol A | |
0.0122 | - |
in 50 mM sodium acetate, pH 4.5, at 25°C | Homo sapiens | eckol | |
0.03647 | - |
in 50 mM sodium acetate, pH 4.5, at 25°C | Homo sapiens | phloroglucinol |