Literature summary for 3.4.23.46 extracted from

Grimm, M.O.; Grimm, H.S.; Tomic, I.; Beyreuther, K.; Hartmann, T.; Bergmann, C.
Independent inhibition of Alzheimer disease beta- and gamma-secretase cleavage by lowered cholesterol levels (2008), J. Biol. Chem., 283, 11302-11311.

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Application

Application	Comment	Organism
medicine	cholesterol depletion within the cellular context inhibits both beta-secretase and gamma-secretase additively and independently from each other. The parallel and additive inhibition may indicate an intrinsic cross-talk between Alzheimer disease-related amyloid precursor protein processing, amyloid precursor protein function, and lipid biology	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	cholesterol depletion within the cellular context inhibits both beta-secretase and gamma-secretase additively and independently from each other. The parallel and additive inhibition may indicate an intrinsic cross-talk between Alzheimer disease-related amyloid precursor protein processing, amyloid precursor protein function, and lipid biology; cyclodextrin does not affect the protein levels of BACE I	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
SH-SY5Y cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
BACE I	-	Homo sapiens
beta-secretase	-	Homo sapiens

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Release 2023.1 (January 2023)