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Literature summary for 3.4.23.46 extracted from
- Decrease in age-adjusted cerebrospinal fluid beta-secretase activity in Alzheimer's subjects (2008), Clin. Biochem., 41, 986-996.
Application
| Application | Comment | Organism |
|---|---|---|
| analysis | development of robust assay for cerebrospinal fluid beta-secretase-1 activity with sensitivity down to 1 pM of recombinant enzyme | Homo sapiens |
| medicine | a small cohort of human subjects displays age-dependent increase in cerebrospinal fluid beta-secretase-1 activity. In Alzheimer's disease subjects, a significant decline in age-adjusted cerebrospinal fluid beta-secretase-1 activity is observed | Homo sapiens |
| medicine | BACE-1 activity is a potential biomarker in human Alzheimer's disease | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in HEK-293 cells | Homo sapiens |
| expressed in HEK-293 cells | Macaca mulatta |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Macaca mulatta | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
- |
Macaca mulatta |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| cerebrospinal fluid | - |
Homo sapiens | - |
| cerebrospinal fluid | - |
Macaca mulatta | - |
| cerebrospinal fluid | development of assay for cerebrospinal fluid beta-secretase-1 activity with sensitivity down to 1 pM of recombinant enzyme. Endogenous secretase-1 enzyme appears to exist as a C-terminally truncated protein. A small cohort of human subjects displays age-dependent increase in cerebrospinal fluid beta-secretase-1 activity. In Alzheimer's disease subjects, a significant decline in age-adjusted cerebrospinal fluid beta-secretase-1 activity is observed | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| biotin-KTEEISEVNFEVEFR + H2O | - |
Homo sapiens | biotin-KTEEISEVNF + EVEFR | - |
? |  |
| biotin-KTEEISEVNFEVEFR + H2O | - |
Macaca mulatta | biotin-KTEEISEVNF + EVEFR | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| BACE-1 | - |
Homo sapiens |
| BACE-1 | - |
Macaca mulatta |
| beta-secretase-1 | - |
Homo sapiens |
| beta-secretase-1 | - |
Macaca mulatta |
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Release 2023.1 (January 2023)
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