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Literature summary for 3.4.23.46 extracted from
- Enhanced activity of hippocampal BACE1 in a mouse model of postmenopausal memory deficits (2008), Neurosci. Lett., 433, 141-145.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | roles of BACE1 in regulation postmenopausal memory effects analyzed | Mus musculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | P56818 | female ICR mice, ovariectomized or sham-operated, treated with or without daily restraint stress conditions for 6 h per day over 3 weeks | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| hippocampus | expression of BACE1 in CA1 and C3 regions analyzed under combination of chronic stress and ovariectomy | Mus musculus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
increased BACE1 activity determined in hippocampal CA1 and CA3 regions of mice tretated by combination of ovariectomy and chronic stress, condition shown to evoke an impairment of hippocampus-dependent memory, association between stressful life after menopause and Alzheimer disease-related molecules suggested, BACE1 discussed as the most sensitive molecule | Mus musculus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | influence of combination of ovariectomy and chronic stress on BACE1 activity analyzed | Mus musculus | ? | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| BACE1 | - |
Mus musculus |
| beta-secretase | - |
Mus musculus |
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Release 2023.1 (January 2023)
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