Any feedback?
Literature summary for 3.4.23.46 extracted from
- A copper-binding site in the cytoplasmic domain of BACE1 identifies a possible link to metal homoeostasis and oxidative stress in Alzheimers disease (2007), Biochem. Soc. Trans., 35, 571-573.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | studies on early pathogenesis of Alzheimers disease, investigation of metal homoeostasis in relation to accumulation of amyloid beta-peptides | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in CHO cells | Homo sapiens |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Cu2+ | involvement of aspartic proteinase BACE1 in copper homoeostasis shown, key role of the central of three cysteines (amino acid 482 in 501-amino-acid isoform of BACE1) in metal binding indicated | Homo sapiens |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P56817 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| Alzheimer specific cell type | metal homeostasis analyzed in | Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
identification of a 24-residue peptide corresponding to the C-terminus of BACE1 that binds a single copper atom with high affinity, cytoplasmic domain of BACE1 shown to interact with dedicated copper chaperone for superoxide dismutase 1, reduced activity of superoxide dismutase 1 by overproduction of BACE1 demonstrated, activity of superoxide dismutase 1, cytosolic copper and ectodomain cleavage of amyloid precursor protein APP shown to be linked through BACE1, quaternary protein complex of BACE1 with associated factors proposed | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | associated role of aspartic proteinase BACE1 in copper homoeostasis shown, link between processing of amyloid precursor protein APP and copper homoeostasis in the brain analyzed | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Aspartic proteinase | - |
Homo sapiens |
| BACE1 | - |
Homo sapiens |
| beta-secretase | - |
Homo sapiens |
| beta-site APP-cleaving enzyme 1 | - |
Homo sapiens |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
