Any feedback?
Literature summary for 3.4.23.46 extracted from
- Heparin activates beta-secretase (BACE1) of Alzheimers disease and increases autocatalysis of the enzyme (2006), Biochemistry, 45, 6703-6714.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| heparin | stimulates the partially active BACE1 zymogen. The activation is mediated by high-affinity binding of heparin to the pro-domain | Homo sapiens |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| heparin | leads to increased autocatalytic cleavage of beta-secretase and a subsequent loss of enzyme activity in vitro | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | identification of autocatalytic cleavage products | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| BACE1 | - |
Homo sapiens |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
