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Literature summary for 3.4.23.46 extracted from

  • Ghosh, A.K.; Hong, L.; Tang, J.
    beta-Secretase as a therapeutic target for inhibitor drugs (2002), Curr. Med. Chem., 9, 1135-1144.
    View publication on PubMed
Search for more literature for 3.4.23.46

Cloned(Commentary)

Cloned (Comment) Organism
overview Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information overview on first generation inhibitors, inhibitor design Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface
-
 Homo sapiens 9986
-
endosome
-
 Homo sapiens 5768
-
Golgi apparatus
-
 Homo sapiens 5794
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens cleaves at the beta-secretase site of Alzheimer's amyloid precursor protein ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Reaction

Reaction Comment Organism Reaction ID
broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-/-Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein suggested to be the major "beta-secretase" responsible for the cleavage of the beta-amyloid precursor protein to form the amyloidogenic beta-peptide that is implicated in the pathology of Alzheimer's disease Homo sapiens
a
broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-/-Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein memapsin 1 and 2 have overlapping yet distinct sequence preference Homo sapiens
a

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
amyloid precursor protein + H2O
-
 Homo sapiens ?
-
 ?
additional information cleaves at the beta-secretase site of Alzheimer's amyloid precursor protein Homo sapiens ?
-
 ?
Swedish variant of amyloid precursor protein + H2O
-
 Homo sapiens ?
-
 ?

pH Range

pH Minimum pH Maximum Comment Organism
3.5 4.5
-
 Homo sapiens