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Literature summary for 3.4.23.46 extracted from
- Inhibition of BACE, a promising approach to Alzheimer's disease therapy (2002), Curr. Top. Med. Chem., 2, 359-370.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Homo sapiens | 16020 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-/-Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein | enzyme is an aspartic protease but is atypical in containing a C-terminal membrane-spanning domain | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| amyloid precursor protein + H2O | - |
Homo sapiens | ? | - |
? |  |
| Swedish variant of amyloid precursor protein + H2O | - |
Homo sapiens | ? | - |
? | |
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Release 2023.1 (January 2023)
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