Literature summary for 3.4.23.46 extracted from

Hong, L.; Turner, R.T.; Koelsch, G.; Shin, D.; Ghosh, A.K.; Tang, J.
Crystal structure of memapsin 2 (b-secretase) in complex with an inhibitor OM00-3 (2002), Biochemistry, 41, 10963-10967.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
in complex with inhibitor OM00-3	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
OM00-3	Glu-Leu-Asp-Leu*Ala-Val-Glu-Phe, the asterisk denotes a hydxoxyethelene transition state isostere	Homo sapiens
OM99-2	Glu-Val-Asn-Leu*Ala-Ala-Glu-Phe, the asterisk denotes a hydxoxyethelene transition state isostere	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
amyloid precursor protein + H2O	-	Homo sapiens	?	-	?
additional information	requirements for substrate subsites	Homo sapiens	?	-	?
Swedish variant of amyloid precursor protein + H2O	-	Homo sapiens	?	-	?

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.0000003	-	OM00-3	-	Homo sapiens
0.000001	-	OM99-2	memapsin 2	Homo sapiens

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Release 2023.1 (January 2023)