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Literature summary for 3.4.23.45 extracted from

  • Esterhazy, D.; Stuetzer, I.; Wang, H.; Rechsteiner, M.P.; Beauchamp, J.; Doebeli, H.; Hilpert, H.; Matile, H.; Prummer, M.; Schmidt, A.; Lieske, N.; Boehm, B.; Marselli, L.; Bosco, D.; Kerr-Conte, J.; Aebersold, R.; Spinas, G.A.; Moch, H.; Migliorini, C.; Stoffel, M.
    Bace2 is a beta cell-enriched protease that regulates pancreatic beta cell function and mass (2011), Cell Metab., 14, 365-377.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
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Mus musculus 16020
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Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
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Source Tissue

Source Tissue Comment Organism Textmining
colon BACE2 mRNA is expressed at much lower levels than in pancreas Mus musculus
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additional information BACE2 expression is virtually absent from all the other tissues Mus musculus
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ovary BACE2 mRNA is expressed at much lower levels than in pancreas Mus musculus
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pancreas Bace2 mRNA expression is highest in pancreatic islets Mus musculus
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pituitary gland BACE2 mRNA is expressed at much lower levels than in pancreas Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Tmem27 + H2O proliferative plasma membrane protein Mus musculus ? BACE2 inactivates Tmem27 by cleavage to release a 25000 Da N-terminal part and a 22000 Da C-terminal fragment ?

General Information

General Information Comment Organism
physiological function mice with functionally inactive Bace2 and insulin-resistant mice treated with a Bace2 inhibitor both display augmented beta cell mass and improved control of glucose homeostasis due to increased insulin levels Mus musculus