Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Mus musculus | 16020 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
colon | BACE2 mRNA is expressed at much lower levels than in pancreas | Mus musculus | - |
additional information | BACE2 expression is virtually absent from all the other tissues | Mus musculus | - |
ovary | BACE2 mRNA is expressed at much lower levels than in pancreas | Mus musculus | - |
pancreas | Bace2 mRNA expression is highest in pancreatic islets | Mus musculus | - |
pituitary gland | BACE2 mRNA is expressed at much lower levels than in pancreas | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Tmem27 + H2O | proliferative plasma membrane protein | Mus musculus | ? | BACE2 inactivates Tmem27 by cleavage to release a 25000 Da N-terminal part and a 22000 Da C-terminal fragment | ? |
General Information | Comment | Organism |
---|---|---|
physiological function | mice with functionally inactive Bace2 and insulin-resistant mice treated with a Bace2 inhibitor both display augmented beta cell mass and improved control of glucose homeostasis due to increased insulin levels | Mus musculus |