Literature summary for 3.4.23.43 extracted from

Linhartova, M.; Bucinska, L.; Halada, P.; Jecmen, T.; Setlik, J.; Komenda, J.; Sobotka, R.
Accumulation of the Type IV prepilin triggers degradation of SecY and YidC and inhibits synthesis of Photosystem II proteins in the cyanobacterium Synechocystis PCC 6803 (2014), Mol. Microbiol., 93, 1207-1223.

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Organism

Organism	UniProt	Comment	Textmining
Synechocystis sp.	P72640	-	-

Synonyms

Synonyms	Comment	Organism
HofD	-	Synechocystis sp.
PilD	-	Synechocystis sp.
type 4 prepilin-like proteins leader peptide-processing enzyme	-	Synechocystis sp.

General Information

General Information	Comment	Organism
physiological function	a prepilin peptidase pilD null mutant accumulates an unprocessed form of the major pilin PilA1 and its non-glycosylated derivative. The mutant strain has aberrant membrane ultrastructure and does not grow photoautotrophically because the synthesis of Photosystem II subunits is abolished. Other membrane components such as Photosystem I and ATP synthase are synthesized at levels comparable to the control strain. Proliferation of the pilD mutant strain is rescued by elimination of the pilA1 gene. PilA1 co-immunoprecipitates with the SecY translocase and the YidC insertase, and both of these essential translocon components are degraded in the mutant	Synechocystis sp.

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Release 2023.1 (January 2023)