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Literature summary for 3.4.23.41 extracted from

  • Wu, M.; Shen, Q.; Yang, Y.; Zhang, S.; Qu, W.; Chen, J.; Sun, H.; Chen, S.
    Disruption of YPS1 and PEP4 genes reduces proteolytic degradation of secreted HSA/PTH in Pichia pastoris GS115 (2013), J. Ind. Microbiol. Biotechnol., 40, 589-599.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
synthesis single disruption of either PEP4 gene or yapsin family member YPS1 gene leads to reduced degradation of recombinant human serum albumin and human parathyroid hormone upon expression in Pichia pastoris. In a PEP4YPS1 double disruptant, more than 80% of the human serum albumin and human parathyroid hormone secreted by the remains intact, after 72 h of incubation, in comparison to only 30% with the wild-type strain Komagataella pastoris

Organism

Organism UniProt Comment Textmining
Komagataella pastoris Q5J879
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Komagataella pastoris GS115 Q5J879
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Synonyms

Synonyms Comment Organism
YPS1
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Komagataella pastoris