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Literature summary for 3.4.23.41 extracted from
- GPI (glycosylphosphatidylinositol)-linked aspartyl proteases regulate vacuole homoeostasis in Candida glabrata (2014), Biochem. J., 458, 323-334.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| [Candida] glabrata | - |
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General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | a Candida glabrata mutant lacking all 11 yapsins, possesses an enlarged vacuole and displays phenotypes similar to deficiency in vacuolar membrane ATPase with elevated metal ion susceptibility in an alkaline pH medium and diminished in vacuolar membrane ATPase activity. the mutant shows elevated polyphosphate levels and diminished cellular carboxypeptidase Y activity. A gross perturbation of cellular homoeostasis in the mutant lacking all yapsins, even in the absence of external stressors, is characterized by reduced levels of ATP and stress metabolites, elevated reactive oxygen species levels, cell surface abnormalities, and a constitutively activated protein kinase C signalling pathway. Isoform Yps1 is involved in the maintenance of ion homoeostasis under normal and calcineurin-inhibited conditions | [Candida] glabrata |
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Release 2023.1 (January 2023)
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