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Literature summary for 3.4.23.41 extracted from
- Specificity and kinetic studies on the cleavage of various prohormone mono- and paired-basic residue sites by yeast aspartic protease 3 (1996), J. Biol. Chem., 271, 4168-4176.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| pepstatin A | - |
Saccharomyces cerevisiae |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0177 | - |
human adrenocorticotropic hormone 1-39 | - |
Saccharomyces cerevisiae | |
| 0.0185 | - |
Proinsulin | - |
Saccharomyces cerevisiae | |
| 0.044 | - |
amidorphin | - |
Saccharomyces cerevisiae | |
| 0.079 | - |
dynorphin B | - |
Saccharomyces cerevisiae | |
| 0.1153 | - |
Cholecystokinin | - |
Saccharomyces cerevisiae | |
| 0.1361 | - |
dynorphin A | - |
Saccharomyces cerevisiae | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Saccharomyces cerevisiae | not known | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| hydrolyses various precursor proteins with Arg or Lys in P1, and commonly Arg or Lys also in P2. The P3 amino acid is usually non-polar, but otherwise additional basic amino acids are favourable in both non-prime and prime positions | cleaves at mono-, di-, and multi-basic cleavage sites | Saccharomyces cerevisiae |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| amidorphin | - |
Saccharomyces cerevisiae | Met-enkephalin-Lys-Lys | - |
? | |
| Cholecystokinin + H2O | - |
Saccharomyces cerevisiae | ? | - |
? | |
| dynorphin A | - |
Saccharomyces cerevisiae | Leu-enkephalin-Arg | - |
? | |
| dynorphin B | - |
Saccharomyces cerevisiae | Leu-enkephalin-Arg-Arg | - |
? | |
| human adrenocorticotropic hormone 1-39 | - |
Saccharomyces cerevisiae | human adrenocorticotropic hormone 1-15 + corticotropin-like intermediate lobe peptide 16-39 | - |
? | |
| additional information | not known | Saccharomyces cerevisiae | ? | - |
? | |
| proinsulin | - |
Saccharomyces cerevisiae | ? | - |
? | |
| synthetic cholecystokinin | - |
Saccharomyces cerevisiae | ? | - |
? | |
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