Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.23.41 extracted from

  • Ledgerwood, E.C.; Brennan, S.O.; Cawley, N.X.; Loh, Y.P.; George, P.M.
    Yeast aspartic protease 3 (Yap3) prefers substrates with basic residues in the P2, P1 and P2 positions (1996), FEBS Lett., 383, 67-71.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
overexpression in yeast Saccharomyces cerevisiae

Inhibitors

Inhibitors Comment Organism Structure
pepstatin A
-
Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Reaction

Reaction Comment Organism Reaction ID
hydrolyses various precursor proteins with Arg or Lys in P1, and commonly Arg or Lys also in P2. The P3 amino acid is usually non-polar, but otherwise additional basic amino acids are favourable in both non-prime and prime positions cleaves at mono-, di-, and multi-basic cleavage sites Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
albumin
-
Saccharomyces cerevisiae ?
-
?
pro-alpha-mating factor
-
Saccharomyces cerevisiae ?
-
?
synthetic proalbumin substrate is representing the propeptide cleavage site RGVFRRDAHKSEVAW Saccharomyces cerevisiae RGVFRR + DEAKSEVAW
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.5
-
-
Saccharomyces cerevisiae