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Literature summary for 3.4.23.41 extracted from
- Yapsin1. Structure, biosynthesis, and specificity (1998), Adv. Exp. Med. Biol., 436, 315-319.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| overexpression in yeast | Saccharomyces cerevisiae |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasmic membrane | facing into the periplasmic space | Saccharomyces cerevisiae | - |
- |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| hydrolyses various precursor proteins with Arg or Lys in P1, and commonly Arg or Lys also in P2. The P3 amino acid is usually non-polar, but otherwise additional basic amino acids are favourable in both non-prime and prime positions | cleavage is enhanced in substrates having additional basic residues flanking the P1 site | Saccharomyces cerevisiae |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| human parathyroid hormone | - |
Saccharomyces cerevisiae | ? | - |
? |  |
| pro-alpha-mating factor | - |
Saccharomyces cerevisiae | ? | - |
? | |
| synthetic cholecystokinin | - |
Saccharomyces cerevisiae | ? | - |
? | |
| synthetic proalbumin | - |
Saccharomyces cerevisiae | RGVFRR + DEAKSEVAW | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 4 | 4.5 | - |
Saccharomyces cerevisiae |
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Release 2023.1 (January 2023)
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