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Literature summary for 3.4.23.39 extracted from

  • Mohapatra, S.C.; Tiwari, H.K.; Singla, M.; Rathi, B.; Sharma, A.; Mahiya, K.; Kumar, M.; Sinha, S.; Chauhan, S.S.
    Antimalarial evaluation of copper(II) nanohybrid solids: inhibition of plasmepsin II, a hemoglobin-degrading malarial aspartic protease from Plasmodium falciparum (2010), J. Biol. Inorg. Chem., 15, 373-385.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli as a recombinant protein Plasmodium falciparum

Inhibitors

Inhibitors Comment Organism Structure
LCu(CH3COO)2 copper(II) nanohybrid solids are synthesized and are shown to be capped by a bis(benzimidazole) diamide ligand (L) Plasmodium falciparum
LCuCl2 copper(II) nanohybrid solids are synthesized and are shown to be capped by a bis(benzimidazole) diamide ligand (L) Plasmodium falciparum
pepstatin A
-
Plasmodium falciparum

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Hemoglobin + H2O
-
Plasmodium falciparum ?
-
?
Lys-Glu-Phe-Val-Phe-4-nitrophenylalanine-Ala-Leu-Lys + H2O
-
Plasmodium falciparum ?
-
?

Synonyms

Synonyms Comment Organism
plasmepsin II
-
Plasmodium falciparum

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Plasmodium falciparum

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
4.7
-
assay at Plasmodium falciparum

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.01
-
LCu(CH3COO)2 pH 4.7, 37°C Plasmodium falciparum
0.013
-
LCuCl2 pH 4.7, 37°C Plasmodium falciparum

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.014
-
pH 4.7, 37°C Plasmodium falciparum LCu(CH3COO)2
0.017
-
pH 4.7, 37°C Plasmodium falciparum LCuCl2