Cloned (Comment) | Organism |
---|---|
recombinantly expressed in Escherichia coli BL21 | Plasmodium falciparum |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(1Z)-N'-{[(4-chloro-3,5-dimethylphenoxy)acetyl]oxy}-2-(3,4-dimethoxyphenyl)ethanimidamide | - |
Plasmodium falciparum | |
2-(1,3-benzothiazol-2-ylamino)-N-(2-chlorophenyl)-6-oxo-1,4,5,6tetrahydro-4-pyrimidinecarboxamide | - |
Plasmodium falciparum | |
2-(1-naphthyl)-N'-[(4-nitrobenzoyl)oxy]ethanimidamide | - |
Plasmodium falciparum | |
2-([N-(2,3-dihydro-1,4-benzodioxin-6-yl)-N-(methylsulfonyl)glycyl]amino)-N-isobutylbenzamide | - |
Plasmodium falciparum | |
2-anilino-3-chloro-N-phenyl-4-(phenylimino)-2-butenamide | - |
Plasmodium falciparum | |
2-anilino-4-(3-furyl)-6-oxo-N-phenyl-1-cyclohexene-1-carboxamide | - |
Plasmodium falciparum | |
3-chloro-N-([2-(2-methoxybenzoyl)hydrazino]carbonothioyl)-1-benzothiophene-2-carboxamide | - |
Plasmodium falciparum | |
4-amino-N'-(benzyloxy)-N-(2-methylphenyl)-1,2,5-oxadiazole-3carboximidamide | - |
Plasmodium falciparum | |
4-amino-N'-(benzyloxy)-N-(4-methylphenyl)-1,2,5-oxadiazole-3carboximidamide | - |
Plasmodium falciparum | |
4-amino-N'-[(2,4-dichlorobenzyl)oxy]-N-(2-methylphenyl)-1,2,5oxadiazole-3-carboximidamide | - |
Plasmodium falciparum | |
4-amino-N'-[(2-methyl-1-naphthyl)methoxy]-1,2,5-oxadiazole-3carboximidamide | - |
Plasmodium falciparum | |
4-methoxy-N-(2-[5-(2-nitrophenyl)-2-furyl]-1-([(4-pyridinylmethyl)amino]carbonyl)vinyl)benzamide | - |
Plasmodium falciparum | |
6-((2-[(5-chloro-2-methoxyphenyl)amino]-2-oxoethyl)thio)-5-cyano-N-(2-methoxyphenyl)-2-methyl-4-phenyl-1,4-dihydro-3-pyridinecarboxamide | - |
Plasmodium falciparum | |
6-bromo-2,3,4,9-tetrahydro-1H-carbazol-1-one Nphenylthiosemicarbazone | - |
Plasmodium falciparum | |
N',N'''-1,2-phenylenebis[N-(3-chlorophenyl)urea] | - |
Plasmodium falciparum | |
N'-[(4-methoxy-3-nitrobenzoyl)oxy]-2-(1-naphthyl)ethanimidamide | - |
Plasmodium falciparum | |
N,N'-([(4,6-dimethyl-2-quinazolinyl)amino]methylylidene)dipropanamide | - |
Plasmodium falciparum | |
N-((2,3-dihydro-1,4-benzodioxin-6-ylamino)[(6-methyl-4-oxo-1,4-dihydro-2-pyrimidinyl)amino]methylene)benzamide | - |
Plasmodium falciparum | |
N-((2,3-dihydro-1,4-benzodioxin-6-ylamino)[(6-oxo-4-propyl-1,6-dihydro-2-pyrimidinyl)amino]methylene)-4-methoxybenzamide | - |
Plasmodium falciparum | |
N-(([2-(4-ethylphenyl)-6-methyl-2H-1,2,3-benzotriazol-5-yl]amino)carbonothioyl)-2-nitrobenzamide | - |
Plasmodium falciparum | |
N-(([6-methyl-2-(4-methylphenyl)-2H-1,2,3-benzotriazol-5-yl]amino)carbonothioyl)-2-nitrobenzamide | - |
Plasmodium falciparum | |
N-(1,3-benzodioxol-5-ylmethyl)-N'-[4-(2-oxo-2H-chromen-3-yl)-1,3thiazol-2-yl]succinamide | - |
Plasmodium falciparum | |
N-(2-([3-(1,3-benzodioxol-5-yl)-3-oxo-1-propen-1-yl]amino)phenyl)-4-nitrobenzenesulfonamide | - |
Plasmodium falciparum | |
N-(2-methoxyphenyl)-2-(5H-[1,2,4]triazino[5,6-b]indol-3ylthio)butanamide | - |
Plasmodium falciparum | |
N-(3,4-dichlorophenyl)-2-[(4,6-dimethyl-2-pyrimidinyl)amino]3a,4,5,6,7,7a-hexahydro-1H-benzimidazole-1-carboxamide | - |
Plasmodium falciparum | |
N-(3,4-dimethylphenyl)-N'-(imino[(4,6,7-trimethyl-2-quinazolinyl)amino]methyl)thiourea | - |
Plasmodium falciparum | |
N-(amino[(4,6-dimethyl-2-quinazolinyl)amino]methylene)-2-(4-chlorophenyl)acetamide | - |
Plasmodium falciparum | |
N-([(2,4-dimethylphenyl)amino][(4-oxo-1,4,5,6,7,8-hexahydro-2-quinazolinyl)amino]methylene)benzamide | - |
Plasmodium falciparum | |
N-benzyl-2-([3-(3-nitrophenyl)acryloyl]amino)benzamide | - |
Plasmodium falciparum | |
N-[(cyclopentylamino)carbonothioyl]-4-ethoxy-3-nitrobenzamide | - |
Plasmodium falciparum | |
pepstatin A | - |
Plasmodium falciparum |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Plasmodium falciparum | - |
- |
- |
Purification (Comment) | Organism |
---|---|
using a Q-Sepharose fast flow column | Plasmodium falciparum |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS + H2O | FRET substrate, substrate is designed to mimic the hemoglobin cleavage site. The substrate is conjugated with the fluorescent donor EDANS and the quencher DABCYL | Plasmodium falciparum | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
plasmepsin II | - |
Plasmodium falciparum |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Plasmodium falciparum |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
4.5 | - |
assay at | Plasmodium falciparum |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0000043 | - |
pH 4.5, 37°C | Plasmodium falciparum | (1Z)-N'-{[(4-chloro-3,5-dimethylphenoxy)acetyl]oxy}-2-(3,4-dimethoxyphenyl)ethanimidamide | |
0.0000045 | - |
pH 4.5, 37°C | Plasmodium falciparum | N-[(cyclopentylamino)carbonothioyl]-4-ethoxy-3-nitrobenzamide | |
0.0000055 | - |
pH 4.5, 37°C | Plasmodium falciparum | 4-amino-N'-[(2,4-dichlorobenzyl)oxy]-N-(2-methylphenyl)-1,2,5oxadiazole-3-carboximidamide | |
0.0000064 | - |
pH 4.5, 37°C | Plasmodium falciparum | 4-amino-N'-(benzyloxy)-N-(2-methylphenyl)-1,2,5-oxadiazole-3carboximidamide | |
0.0000076 | - |
pH 4.5, 37°C | Plasmodium falciparum | N',N'''-1,2-phenylenebis[N-(3-chlorophenyl)urea] | |
0.0000088 | - |
pH 4.5, 37°C | Plasmodium falciparum | N-([(2,4-dimethylphenyl)amino][(4-oxo-1,4,5,6,7,8-hexahydro-2-quinazolinyl)amino]methylene)benzamide | |
0.0000095 | - |
pH 4.5, 37°C | Plasmodium falciparum | N-(3,4-dichlorophenyl)-2-[(4,6-dimethyl-2-pyrimidinyl)amino]3a,4,5,6,7,7a-hexahydro-1H-benzimidazole-1-carboxamide | |
0.00003 | - |
pH 4.5, 37°C | Plasmodium falciparum | N-benzyl-2-([3-(3-nitrophenyl)acryloyl]amino)benzamide | |
0.0000389 | - |
pH 4.5, 37°C | Plasmodium falciparum | N-(2-([3-(1,3-benzodioxol-5-yl)-3-oxo-1-propen-1-yl]amino)phenyl)-4-nitrobenzenesulfonamide | |
0.0000426 | - |
pH 4.5, 37°C | Plasmodium falciparum | 4-amino-N'-[(2-methyl-1-naphthyl)methoxy]-1,2,5-oxadiazole-3carboximidamide | |
0.0000573 | - |
pH 4.5, 37°C | Plasmodium falciparum | 6-((2-[(5-chloro-2-methoxyphenyl)amino]-2-oxoethyl)thio)-5-cyano-N-(2-methoxyphenyl)-2-methyl-4-phenyl-1,4-dihydro-3-pyridinecarboxamide | |
0.0000621 | - |
pH 4.5, 37°C | Plasmodium falciparum | N-((2,3-dihydro-1,4-benzodioxin-6-ylamino)[(6-methyl-4-oxo-1,4-dihydro-2-pyrimidinyl)amino]methylene)benzamide | |
0.0000875 | - |
pH 4.5, 37°C | Plasmodium falciparum | pepstatin A | |
0.0000875 | - |
pH 4.5, 37°C | Plasmodium falciparum | N-(2-methoxyphenyl)-2-(5H-[1,2,4]triazino[5,6-b]indol-3ylthio)butanamide | |
0.0000961 | - |
pH 4.5, 37°C | Plasmodium falciparum | 2-(1,3-benzothiazol-2-ylamino)-N-(2-chlorophenyl)-6-oxo-1,4,5,6tetrahydro-4-pyrimidinecarboxamide | |
0.0001181 | - |
pH 4.5, 37°C | Plasmodium falciparum | N-((2,3-dihydro-1,4-benzodioxin-6-ylamino)[(6-oxo-4-propyl-1,6-dihydro-2-pyrimidinyl)amino]methylene)-4-methoxybenzamide | |
0.0001229 | - |
pH 4.5, 37°C | Plasmodium falciparum | N-(([6-methyl-2-(4-methylphenyl)-2H-1,2,3-benzotriazol-5-yl]amino)carbonothioyl)-2-nitrobenzamide | |
0.0001452 | - |
pH 4.5, 37°C | Plasmodium falciparum | 2-(1-naphthyl)-N'-[(4-nitrobenzoyl)oxy]ethanimidamide | |
0.0001464 | - |
pH 4.5, 37°C | Plasmodium falciparum | N-(([2-(4-ethylphenyl)-6-methyl-2H-1,2,3-benzotriazol-5-yl]amino)carbonothioyl)-2-nitrobenzamide | |
0.0001871 | - |
pH 4.5, 37°C | Plasmodium falciparum | 2-anilino-4-(3-furyl)-6-oxo-N-phenyl-1-cyclohexene-1-carboxamide | |
0.000189 | - |
pH 4.5, 37°C | Plasmodium falciparum | 2-anilino-3-chloro-N-phenyl-4-(phenylimino)-2-butenamide | |
0.0002011 | - |
pH 4.5, 37°C | Plasmodium falciparum | 3-chloro-N-([2-(2-methoxybenzoyl)hydrazino]carbonothioyl)-1-benzothiophene-2-carboxamide | |
0.0002364 | - |
pH 4.5, 37°C | Plasmodium falciparum | N'-[(4-methoxy-3-nitrobenzoyl)oxy]-2-(1-naphthyl)ethanimidamide | |
0.0002374 | - |
pH 4.5, 37°C | Plasmodium falciparum | N,N'-([(4,6-dimethyl-2-quinazolinyl)amino]methylylidene)dipropanamide | |
0.000305 | - |
pH 4.5, 37°C | Plasmodium falciparum | 4-amino-N'-(benzyloxy)-N-(4-methylphenyl)-1,2,5-oxadiazole-3carboximidamide | |
0.001088 | - |
pH 4.5, 37°C | Plasmodium falciparum | N-(3,4-dimethylphenyl)-N'-(imino[(4,6,7-trimethyl-2-quinazolinyl)amino]methyl)thiourea | |
0.001831 | - |
pH 4.5, 37°C | Plasmodium falciparum | 6-bromo-2,3,4,9-tetrahydro-1H-carbazol-1-one Nphenylthiosemicarbazone |