Literature summary for 3.4.23.39 extracted from

Prade, L.; Jones, A.F.; Boss, C.; Richard-Bildstein, S.; Meyer, S.; Binkert, C.; Bur, D.
X-ray structure of plasmepsin II complexed with a potent achiral inhibitor (2005), J. Biol. Chem., 280, 23837-23843.

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Cloned(Commentary)

Cloned (Comment)	Organism
DNA encoding the last 48 residues of the pro-part and the whole mature sequence of Plasmodium falciparum plasmepsin II is cloned into the T7-dependent vector pET3a for expression in Escherichia coli BL21	Plasmodium falciparum

Crystallization (Commentary)

Crystallization (Comment)	Organism
hanging drop method, X-ray structure of plasmepsin II complexed with the potent non-peptidomimetic achiral inhibitor at 1.6 A	Plasmodium falciparum

Inhibitors

Inhibitors	Comment	Organism	Structure
methyl [4'-(([1-(1H-imidazol-2-ylmethyl)piperidin-4-yl][(4-pentylphenyl)carbonyl]amino)methyl)biphenyl-4-yl]acetate	-	Plasmodium falciparum

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
Hemoglobin + H2O	Plasmodium falciparum	-	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Plasmodium falciparum	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Plasmodium falciparum

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Hemoglobin + H2O	-	Plasmodium falciparum	?	-	?

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Release 2023.1 (January 2023)