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Literature summary for 3.4.23.39 extracted from

  • Boss, C.; Richard-Bildstein, S.; Furnari, R.; Bourgeois, J.; Corminboeuf, O.; Grisostomi, C.; Coppex, L.; Harris, L.; Prade, L.; Meyer, S.; Binkert, C.; Fischli, W.; Brun, R.; Weller, T.
    Inhibitors of plasmepsin II - potential antimalarial agents (2004), Chimia, 58, 634-639.
No PubMed abstract available
Search for more literature for 3.4.23.39

Application

Application Comment Organism
medicine inhibitors of plasmepsin II are potential antimalarial agents Plasmodium falciparum

Inhibitors

Inhibitors Comment Organism Structure
2-([4'-(([2-(dibutylamino)ethyl](4-pentylbenzyl)amino)methyl)biphenyl-4-yl]oxy)ethanol IC50: 441 nM Plasmodium falciparum
2-[4'-(([2-(dibutylamino)ethyl](4-pentylbenzyl)amino)methyl)biphenyl-4-yl]ethanol IC50: 0.00147 mM Plasmodium falciparum
4'-(([2-(dibutylamino)ethyl](4-pentylbenzyl)amino)methyl)biphenyl-4-carbonitrile IC50: 713 nM; IC50: 918 nM Plasmodium falciparum
4'-(([2-(dibutylamino)ethyl](phenylcarbonyl)amino)methyl)biphenyl-3-carboxylic acid IC50: 208 nM Plasmodium falciparum
4'-(([2-(dibutylamino)ethyl](phenylcarbonyl)amino)methyl)biphenyl-4-carboxylic acid IC50: 495 nM Plasmodium falciparum
4-butoxy-N-[2-(dibutylamino)ethyl]-N-(3-phenoxybenzyl)benzamide IC50: 0.0059 mM Plasmodium falciparum
4-butoxy-N-[2-(dibutylamino)ethyl]-N-[4-(trifluoromethyl)benzyl]benzamide IC50: 0.0103 mM Plasmodium falciparum
4-butyl-N-[2-(dibutylamino)ethyl]-N-(3-phenoxybenzyl)benzamide IC50: 0.0023 mM Plasmodium falciparum
4-butyl-N-[2-(dibutylamino)ethyl]-N-[4-(trifluoromethyl)benzyl]benzamide IC50: 0.0039 mM Plasmodium falciparum
methyl [4'-(([2-(dibutylamino)ethyl](phenylcarbonyl)amino)methyl)biphenyl-4-yl]acetate IC50: 124 nM Plasmodium falciparum
N,N-dibutyl-N'-(4-pentylbenzyl)-N'-(4-pyridin-2-ylbenzyl)ethane-1,2-diamine IC50: 0.0013 mM Plasmodium falciparum
N,N-dibutyl-N'-(4-pentylbenzyl)-N'-(4-pyridin-4-ylbenzyl)ethane-1,2-diamine IC50: 0.001603 mM Plasmodium falciparum
N,N-dibutyl-N'-(4-pentylbenzyl)-N'-(4-pyrimidin-5-ylbenzyl)ethane-1,2-diamine IC50: 0.001631 nM Plasmodium falciparum
N,N-dibutyl-N'-(4-pentylbenzyl)-N'-([4'-(2-pyrrolidin-1-ylethoxy)biphenyl-4-yl]methyl)ethane-1,2-diamine IC50: 0.002 mM Plasmodium falciparum
N,N-dibutyl-N'-[(2'-fluorobiphenyl-4-yl)methyl]-N'-(4-pentylbenzyl)ethane-1,2-diamine IC50: 0.001022 mM Plasmodium falciparum
N-(2-aminoethyl)-N-(biphenyl-4-ylmethyl)-4-pentylbenzamide IC50: 0.003329 nM Plasmodium falciparum
N-(biphenyl-4-ylmethyl)-4-butoxy-N-[2-(dibutylamino)ethyl]benzamide IC50: 0.0047 mM Plasmodium falciparum
N-(biphenyl-4-ylmethyl)-4-butyl-N-[2-(dibutylamino)ethyl]benzamide IC50: 0.0015 mM Plasmodium falciparum
N-(biphenyl-4-ylmethyl)-N',N'-dibutyl-N-(4-pentylbenzyl)ethane-1,2-diamine IC50: 0.002067 mM Plasmodium falciparum
N-(biphenyl-4-ylmethyl)-N-(2-[bis(1-methylethyl)amino]ethyl)-4-pentylbenzamide IC50: 0.003943 mM Plasmodium falciparum
N-(biphenyl-4-ylmethyl)-N-[2-(butylamino)ethyl]-4-pentylbenzamide IC50: 0.001161 mM Plasmodium falciparum
N-(biphenyl-4-ylmethyl)-N-[2-(dibutylamino)ethyl]-4-pentylbenzamide IC50: 252 nM Plasmodium falciparum
N-(biphenyl-4-ylmethyl)-N-[2-(dibutylamino)ethyl]-4-propylbenzamide IC50: 0.0129 mM Plasmodium falciparum
N-(biphenyl-4-ylmethyl)-N-[2-(diethylamino)ethyl]-4-pentylbenzamide IC50: 0.002317 mM Plasmodium falciparum
N-([3',5'-bis(trifluoromethyl)biphenyl-4-yl]methyl)-N-[2-(dibutylamino)ethyl]benzamide IC50: 0.0017 mM Plasmodium falciparum
N-([3',5'-bis(trifluoromethyl)biphenyl-4-yl]methyl)-N-[3-(dibutylamino)propyl]-4-pentylbenzamide IC50: 0.00119 mM Plasmodium falciparum
N-[(2'-chlorobiphenyl-4-yl)methyl]-N-[2-(dibutylamino)ethyl]benzamide IC50: 191 nM Plasmodium falciparum
N-[(4'-butylbiphenyl-4-yl)methyl]-N-[2-(dibutylamino)ethyl]benzamide IC50: 591 nM Plasmodium falciparum
N-[(4'-chlorobiphenyl-4-yl)methyl]-N-[2-(dibutylamino)ethyl]benzamide IC50: 446 nM Plasmodium falciparum
N-[(4'-chlorobiphenyl-4-yl)methyl]-N-[3-(dibutylamino)propyl]-4-pentylbenzamide IC50: 407 nM Plasmodium falciparum
N-[(4'-cyanobiphenyl-4-yl)methyl]-N-[2-(dibutylamino)ethyl]benzamide IC50: 160 nM Plasmodium falciparum
N-[2-(dibutylamino)ethyl]-4-pentyl-N-(3-phenoxybenzyl)benzamide IC50: 469 nM Plasmodium falciparum
N-[2-(dibutylamino)ethyl]-4-pentyl-N-[4-(trifluoromethyl)benzyl]benzamide IC50: 596 nM Plasmodium falciparum
N-[2-(dibutylamino)ethyl]-4-propyl-N-[4-(trifluoromethyl)benzyl]benzamide IC50: 0.0396 mM Plasmodium falciparum
N-[2-(dibutylamino)ethyl]-N-(3-phenoxybenzyl)-4-propylbenzamide IC50: 0.0159 mM Plasmodium falciparum
N-[2-(dibutylamino)ethyl]-N-(4-pyridin-4-ylbenzyl)benzamide IC50: 295 nM Plasmodium falciparum
N-[2-(dibutylamino)ethyl]-N-(4-pyrimidin-5-ylbenzyl)benzamide IC50: 204 nM; IC50: 351 nM Plasmodium falciparum
N-[2-(dibutylamino)ethyl]-N-([3'-(trifluoromethyl)biphenyl-4-yl]methyl)benzamide IC50: 390 nM Plasmodium falciparum
N-[2-(dibutylamino)ethyl]-N-([4'-(2-hydroxyethoxy)biphenyl-4-yl]methyl)benzamide IC50: 104 nM Plasmodium falciparum
N-[2-(dibutylamino)ethyl]-N-([4'-(2-hydroxyethyl)biphenyl-4-yl]methyl)benzamide IC50: 151 nM Plasmodium falciparum
N-[2-(dibutylamino)ethyl]-N-[(3',4'-dimethoxybiphenyl-4-yl)methyl]benzamide IC50: 428 nM Plasmodium falciparum
N-[2-(dibutylamino)ethyl]-N-[(3'-methylbiphenyl-4-yl)methyl]benzamide IC50: 293 nM Plasmodium falciparum
N-[3-(dibutylamino)propyl]-4-pentyl-N-([4'-(2-pyrrolidin-1-ylethoxy)biphenyl-4-yl]methyl)benzamide IC50: 221 nM Plasmodium falciparum
N-[3-(dibutylamino)propyl]-N-[(2'-methoxybiphenyl-4-yl)methyl]-4-pentylbenzamide IC50: 0.0011 mM; IC50: 322 nM Plasmodium falciparum
N-[3-(dibutylamino)propyl]-N-[(2'-methylbiphenyl-4-yl)methyl]-4-pentylbenzamide IC50: 597 nM Plasmodium falciparum
N-[3-(dibutylamino)propyl]-N-[(3',4'-dimethoxybiphenyl-4-yl)methyl]-4-pentylbenzamide IC50: 468 nM Plasmodium falciparum
N-[3-(dibutylamino)propyl]-N-[(3'-methoxybiphenyl-4-yl)methyl]-4-pentylbenzamide IC50: 580 nM Plasmodium falciparum
N-[3-(dibutylamino)propyl]-N-[(4'-methoxybiphenyl-4-yl)methyl]-4-pentylbenzamide IC50: 246 nM Plasmodium falciparum
N-[4-(1,3-benzodioxol-5-yl)benzyl]-N',N'-dibutyl-N-(4-pentylbenzyl)ethane-1,2-diamine IC50: 831 nM Plasmodium falciparum
N-[4-(1,3-benzodioxol-5-yl)benzyl]-N-[2-(dibutylamino)ethyl]benzamide IC50: 56 nM Plasmodium falciparum
N-[4-(1,3-benzodioxol-5-yl)benzyl]-N-[3-(dibutylamino)propyl]-4-pentylbenzamide IC50:195 nM Plasmodium falciparum
N-[4-(benzyloxy)benzyl]-4-butoxy-N-[2-(dibutylamino)ethyl]benzamide IC50: 0.0034 mM Plasmodium falciparum
N-[4-(benzyloxy)benzyl]-4-butyl-N-[2-(dibutylamino)ethyl]benzamide IC50: 0.0013 mM Plasmodium falciparum
N-[4-(benzyloxy)benzyl]-N',N'-dibutyl-N-(4-pentylbenzyl)ethane-1,2-diamine IC50: 845 nM Plasmodium falciparum
N-[4-(benzyloxy)benzyl]-N-[2-(dibutylamino)ethyl]-4-pentylbenzamide IC50: 112 nM Plasmodium falciparum
N-[4-(benzyloxy)benzyl]-N-[2-(dibutylamino)ethyl]-4-propylbenzamide IC50: 0.0089 mM Plasmodium falciparum
[4'-(([2-(dibutylamino)ethyl](phenylcarbonyl)amino)methyl)biphenyl-4-yl]acetic acid IC50: 197 nM Plasmodium falciparum

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum
-
-
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000000001631
-
 IC50: 0.001631 nM Plasmodium falciparum N,N-dibutyl-N'-(4-pentylbenzyl)-N'-(4-pyrimidin-5-ylbenzyl)ethane-1,2-diamine
0.000000003329
-
 IC50: 0.003329 nM Plasmodium falciparum N-(2-aminoethyl)-N-(biphenyl-4-ylmethyl)-4-pentylbenzamide
0.000056
-
 IC50: 56 nM Plasmodium falciparum N-[4-(1,3-benzodioxol-5-yl)benzyl]-N-[2-(dibutylamino)ethyl]benzamide
0.000104
-
 IC50: 104 nM Plasmodium falciparum N-[2-(dibutylamino)ethyl]-N-([4'-(2-hydroxyethoxy)biphenyl-4-yl]methyl)benzamide
0.000112
-
 IC50: 112 nM Plasmodium falciparum N-[4-(benzyloxy)benzyl]-N-[2-(dibutylamino)ethyl]-4-pentylbenzamide
0.000124
-
 IC50: 124 nM Plasmodium falciparum methyl [4'-(([2-(dibutylamino)ethyl](phenylcarbonyl)amino)methyl)biphenyl-4-yl]acetate
0.000151
-
 IC50: 151 nM Plasmodium falciparum N-[2-(dibutylamino)ethyl]-N-([4'-(2-hydroxyethyl)biphenyl-4-yl]methyl)benzamide
0.00016
-
 IC50: 160 nM Plasmodium falciparum N-[(4'-cyanobiphenyl-4-yl)methyl]-N-[2-(dibutylamino)ethyl]benzamide
0.000191
-
 IC50: 191 nM Plasmodium falciparum N-[(2'-chlorobiphenyl-4-yl)methyl]-N-[2-(dibutylamino)ethyl]benzamide
0.000195
-
 IC50:195 nM Plasmodium falciparum N-[4-(1,3-benzodioxol-5-yl)benzyl]-N-[3-(dibutylamino)propyl]-4-pentylbenzamide
0.000197
-
 IC50: 197 nM Plasmodium falciparum [4'-(([2-(dibutylamino)ethyl](phenylcarbonyl)amino)methyl)biphenyl-4-yl]acetic acid
0.000204
-
 IC50: 204 nM Plasmodium falciparum N-[2-(dibutylamino)ethyl]-N-(4-pyrimidin-5-ylbenzyl)benzamide
0.000208
-
 IC50: 208 nM Plasmodium falciparum 4'-(([2-(dibutylamino)ethyl](phenylcarbonyl)amino)methyl)biphenyl-3-carboxylic acid
0.000221
-
 IC50: 221 nM Plasmodium falciparum N-[3-(dibutylamino)propyl]-4-pentyl-N-([4'-(2-pyrrolidin-1-ylethoxy)biphenyl-4-yl]methyl)benzamide
0.000246
-
 IC50: 246 nM Plasmodium falciparum N-[3-(dibutylamino)propyl]-N-[(4'-methoxybiphenyl-4-yl)methyl]-4-pentylbenzamide
0.000252
-
 IC50: 252 nM Plasmodium falciparum N-(biphenyl-4-ylmethyl)-N-[2-(dibutylamino)ethyl]-4-pentylbenzamide
0.000293
-
 IC50: 293 nM Plasmodium falciparum N-[2-(dibutylamino)ethyl]-N-[(3'-methylbiphenyl-4-yl)methyl]benzamide
0.000295
-
 IC50: 295 nM Plasmodium falciparum N-[2-(dibutylamino)ethyl]-N-(4-pyridin-4-ylbenzyl)benzamide
0.000322
-
 IC50: 322 nM Plasmodium falciparum N-[3-(dibutylamino)propyl]-N-[(2'-methoxybiphenyl-4-yl)methyl]-4-pentylbenzamide
0.000351
-
 IC50: 351 nM Plasmodium falciparum N-[2-(dibutylamino)ethyl]-N-(4-pyrimidin-5-ylbenzyl)benzamide
0.00039
-
 IC50: 390 nM Plasmodium falciparum N-[2-(dibutylamino)ethyl]-N-([3'-(trifluoromethyl)biphenyl-4-yl]methyl)benzamide
0.000407
-
 IC50: 407 nM Plasmodium falciparum N-[(4'-chlorobiphenyl-4-yl)methyl]-N-[3-(dibutylamino)propyl]-4-pentylbenzamide
0.000428
-
 IC50: 428 nM Plasmodium falciparum N-[2-(dibutylamino)ethyl]-N-[(3',4'-dimethoxybiphenyl-4-yl)methyl]benzamide
0.000441
-
 IC50: 441 nM Plasmodium falciparum 2-([4'-(([2-(dibutylamino)ethyl](4-pentylbenzyl)amino)methyl)biphenyl-4-yl]oxy)ethanol
0.000446
-
 IC50: 446 nM Plasmodium falciparum N-[(4'-chlorobiphenyl-4-yl)methyl]-N-[2-(dibutylamino)ethyl]benzamide
0.000468
-
 IC50: 468 nM Plasmodium falciparum N-[3-(dibutylamino)propyl]-N-[(3',4'-dimethoxybiphenyl-4-yl)methyl]-4-pentylbenzamide
0.000469
-
 IC50: 469 nM Plasmodium falciparum N-[2-(dibutylamino)ethyl]-4-pentyl-N-(3-phenoxybenzyl)benzamide
0.000495
-
 IC50: 495 nM Plasmodium falciparum 4'-(([2-(dibutylamino)ethyl](phenylcarbonyl)amino)methyl)biphenyl-4-carboxylic acid
0.00058
-
 IC50: 580 nM Plasmodium falciparum N-[3-(dibutylamino)propyl]-N-[(3'-methoxybiphenyl-4-yl)methyl]-4-pentylbenzamide
0.000591
-
 IC50: 591 nM Plasmodium falciparum N-[(4'-butylbiphenyl-4-yl)methyl]-N-[2-(dibutylamino)ethyl]benzamide
0.000596
-
 IC50: 596 nM Plasmodium falciparum N-[2-(dibutylamino)ethyl]-4-pentyl-N-[4-(trifluoromethyl)benzyl]benzamide
0.000597
-
 IC50: 597 nM Plasmodium falciparum N-[3-(dibutylamino)propyl]-N-[(2'-methylbiphenyl-4-yl)methyl]-4-pentylbenzamide
0.000713
-
 IC50: 713 nM Plasmodium falciparum 4'-(([2-(dibutylamino)ethyl](4-pentylbenzyl)amino)methyl)biphenyl-4-carbonitrile
0.000831
-
 IC50: 831 nM Plasmodium falciparum N-[4-(1,3-benzodioxol-5-yl)benzyl]-N',N'-dibutyl-N-(4-pentylbenzyl)ethane-1,2-diamine
0.000845
-
 IC50: 845 nM Plasmodium falciparum N-[4-(benzyloxy)benzyl]-N',N'-dibutyl-N-(4-pentylbenzyl)ethane-1,2-diamine
0.000918
-
 IC50: 918 nM Plasmodium falciparum 4'-(([2-(dibutylamino)ethyl](4-pentylbenzyl)amino)methyl)biphenyl-4-carbonitrile
0.001022
-
 IC50: 0.001022 mM Plasmodium falciparum N,N-dibutyl-N'-[(2'-fluorobiphenyl-4-yl)methyl]-N'-(4-pentylbenzyl)ethane-1,2-diamine
0.0011
-
 IC50: 0.0011 mM Plasmodium falciparum N-[3-(dibutylamino)propyl]-N-[(2'-methoxybiphenyl-4-yl)methyl]-4-pentylbenzamide
0.001161
-
 IC50: 0.001161 mM Plasmodium falciparum N-(biphenyl-4-ylmethyl)-N-[2-(butylamino)ethyl]-4-pentylbenzamide
0.00119
-
 IC50: 0.00119 mM Plasmodium falciparum N-([3',5'-bis(trifluoromethyl)biphenyl-4-yl]methyl)-N-[3-(dibutylamino)propyl]-4-pentylbenzamide
0.0013
-
 IC50: 0.0013 mM Plasmodium falciparum N-[4-(benzyloxy)benzyl]-4-butyl-N-[2-(dibutylamino)ethyl]benzamide
0.0013
-
 IC50: 0.0013 mM Plasmodium falciparum N,N-dibutyl-N'-(4-pentylbenzyl)-N'-(4-pyridin-2-ylbenzyl)ethane-1,2-diamine
0.00147
-
 IC50: 0.00147 mM Plasmodium falciparum 2-[4'-(([2-(dibutylamino)ethyl](4-pentylbenzyl)amino)methyl)biphenyl-4-yl]ethanol
0.0015
-
 IC50: 0.0015 mM Plasmodium falciparum N-(biphenyl-4-ylmethyl)-4-butyl-N-[2-(dibutylamino)ethyl]benzamide
0.001603
-
 IC50: 0.001603 mM Plasmodium falciparum N,N-dibutyl-N'-(4-pentylbenzyl)-N'-(4-pyridin-4-ylbenzyl)ethane-1,2-diamine
0.0017
-
 IC50: 0.0017 mM Plasmodium falciparum N-([3',5'-bis(trifluoromethyl)biphenyl-4-yl]methyl)-N-[2-(dibutylamino)ethyl]benzamide
0.002
-
 IC50: 0.002 mM Plasmodium falciparum N,N-dibutyl-N'-(4-pentylbenzyl)-N'-([4'-(2-pyrrolidin-1-ylethoxy)biphenyl-4-yl]methyl)ethane-1,2-diamine
0.002067
-
 IC50: 0.002067 mM Plasmodium falciparum N-(biphenyl-4-ylmethyl)-N',N'-dibutyl-N-(4-pentylbenzyl)ethane-1,2-diamine
0.0023
-
 IC50: 0.0023 mM Plasmodium falciparum 4-butyl-N-[2-(dibutylamino)ethyl]-N-(3-phenoxybenzyl)benzamide
0.002317
-
 IC50: 0.002317 mM Plasmodium falciparum N-(biphenyl-4-ylmethyl)-N-[2-(diethylamino)ethyl]-4-pentylbenzamide
0.0034
-
 IC50: 0.0034 mM Plasmodium falciparum N-[4-(benzyloxy)benzyl]-4-butoxy-N-[2-(dibutylamino)ethyl]benzamide
0.0039
-
 IC50: 0.0039 mM Plasmodium falciparum 4-butyl-N-[2-(dibutylamino)ethyl]-N-[4-(trifluoromethyl)benzyl]benzamide
0.003943
-
 IC50: 0.003943 mM Plasmodium falciparum N-(biphenyl-4-ylmethyl)-N-(2-[bis(1-methylethyl)amino]ethyl)-4-pentylbenzamide
0.0047
-
 IC50: 0.0047 mM Plasmodium falciparum N-(biphenyl-4-ylmethyl)-4-butoxy-N-[2-(dibutylamino)ethyl]benzamide
0.0059
-
 IC50: 0.0059 mM Plasmodium falciparum 4-butoxy-N-[2-(dibutylamino)ethyl]-N-(3-phenoxybenzyl)benzamide
0.0089
-
 IC50: 0.0089 mM Plasmodium falciparum N-[4-(benzyloxy)benzyl]-N-[2-(dibutylamino)ethyl]-4-propylbenzamide
0.0103
-
 IC50: 0.0103 mM Plasmodium falciparum 4-butoxy-N-[2-(dibutylamino)ethyl]-N-[4-(trifluoromethyl)benzyl]benzamide
0.0129
-
 IC50: 0.0129 mM Plasmodium falciparum N-(biphenyl-4-ylmethyl)-N-[2-(dibutylamino)ethyl]-4-propylbenzamide
0.0159
-
 IC50: 0.0159 mM Plasmodium falciparum N-[2-(dibutylamino)ethyl]-N-(3-phenoxybenzyl)-4-propylbenzamide
0.0396
-
 IC50: 0.0396 mM Plasmodium falciparum N-[2-(dibutylamino)ethyl]-4-propyl-N-[4-(trifluoromethyl)benzyl]benzamide